BECN1 and MDM4

Number of citations of the paper that reports this interaction (PubMedID 28205554)
32

Data Source:
BioGRID (fluorescent resonance energy transfer)

		BECN1	MDM4
Description		beclin 1	MDM4 regulator of p53
Image
GO Annotations	Cellular Component	Phagophore Assembly Site Cell Nucleus Mitochondrion Endosome Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Endosome Membrane Extrinsic Component Of Membrane Mitochondrial Membrane Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Phosphatidylinositol 3-kinase Binding GTPase Binding	Protein Binding Zinc Ion Binding Enzyme Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Endocytosis Autophagy Apoptotic Process Cellular Defense Response Cellular Response To Nitrogen Starvation Mitotic Metaphase Plate Congression Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Macroautophagy Protein Deubiquitination Protein Localization By The Cvt Pathway Regulation Of Cytokinesis Receptor Catabolic Process Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Early Endosome To Late Endosome Transport Late Endosome To Vacuole Transport Cell Division Defense Response To Virus Negative Regulation Of Cell Death Response To Mitochondrial Depolarisation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Heart Valve Development Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Ventricular Septum Development Atrial Septum Development DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Cell Proliferation Protein Deubiquitination DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Protein Stabilization Protein-containing Complex Assembly Negative Regulation Of Cell Cycle Arrest Cellular Response To Hypoxia Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Macroautophagy Ub-specific processing proteases	Oxidative Stress Induced Senescence Oncogene Induced Senescence Ub-specific processing proteases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Stabilization of p53
Drugs		Estradiol
Diseases
GWAS		Type 2 diabetes (age of onset) ( 28060188)	Breast cancer ( 23535733 27117709) Breast cancer (estrogen-receptor negative) ( 27117709 29058716) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast Cancer in BRCA1 mutation carriers ( 23544013) Cognitive performance ( 19734545) Diastolic blood pressure ( 27618452 30578418) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Glioma ( 28346443) Non-glioblastoma glioma ( 28346443) Prostate cancer ( 23535732) Regular attendance at a religious group ( 29970889) Systolic blood pressure ( 27618452)
Interacting Genes		50 interacting genes: AKT1 AMBRA1 ARAF ARNT ATG3 BCL2 BCL2L1 BTK CASP3 CCND2 CDK4 CDK6 CDKN2A CDKN2B EPHA2 ERBB2 FGFR4 FRS2 FZR1 GFI1B GLIS2 GOPC GRM1 ITCH KAT2A KDELR2 LATS2 MAP2K3 MAP2K5 MAP2K6 MAPKAPK2 MAPKAPK3 MDM4 NF2 PDGFRA PGK1 RACK1 RAF1 SHD SMAD2 STK11 TEAD2 TERT TRAF2 TSC1 UBC ULK1 WASHC1 XPO1 YES1	58 interacting genes: AKT1 APP ARF1 ATM BECN1 CAPN7 CASP3 CBLC CD160 CD44 CDK1 CDK4 CDKN2A CDKN2B CHEK1 CHEK2 CSNK1A1 E2F1 EP300 EPHA2 FGFR4 GLIS2 HGF LATS2 LRSAM1 MAGEA1 MAP2K5 MDM2 MKRN3 MNAT1 NF2 PELI1 PRKAA1 RAD54B RB1 RNF115 S100B SFN SMAD3 SMAD4 SMARCA2 TP53 TP63 TP73 TRIM46 TRIM55 UBC UBE2D1 UBE2D2 UBE2D3 USP7 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZKSCAN4
Entrez ID		8678	4194
HPRD ID		05087	04082
Ensembl ID		ENSG00000126581	ENSG00000198625
Uniprot IDs		A0A024R1X5 B4DQ36 E7EV84 Q14457 W0FFG4	A0A087WTR9 A0A087WUE3 A0A087WZ58 O15151 Q59FS6 Q68DC0
PDB IDs		2P1L 2PON 3DVU 4DDP 4MI8 5EFM 5HHE 5VAU 5VAX 5VAY 6DCN 6DCO 6HOI 6HOJ 6HOK	2CR8 2MWY 2N06 2N0U 2N0W 2N14 2VJE 2VJF 2VYR 3DAB 3EQY 3FDO 3FE7 3FEA 3JZO 3JZP 3JZQ 3LBJ 3MQR 3U15 4RXZ 5MNJ 5UML 5VK1 6Q9Q 6Q9S 6Q9U 6Q9W 6Q9Y
Enriched GO Terms of Interacting Partners?
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