TNK2 and BAG3

Number of citations of the paper that reports this interaction (PubMedID 26496610)
285

Data Source:
BioGRID (affinity chromatography technology, pull down)

		TNK2	BAG3
Description		tyrosine kinase non receptor 2	BAG cochaperone 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Plasma Membrane Clathrin-coated Pit Adherens Junction Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm Grb2-EGFR Complex Cytoophidium	Stress Fiber Cell Nucleus Cytoplasm Cytosol Plasma Membrane Aggresome Z Disc Neuron Projection Chaperone Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity GTPase Inhibitor Activity Signaling Receptor Binding Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding WW Domain Binding	Adenyl-nucleotide Exchange Factor Activity Protein Binding Protein-containing Complex Binding Cadherin Binding Dynein Intermediate Chain Binding Chaperone Binding
	Biological Process	Endocytosis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Small GTPase Mediated Signal Transduction Phosphorylation Cell Differentiation Negative Regulation Of GTPase Activity Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Clathrin-dependent Endocytosis	Autophagosome Assembly Protein Folding Brain Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Striated Muscle Cell Apoptotic Process Spinal Cord Development Cellular Response To Heat Cellular Response To Unfolded Protein Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Muscle Cell Cellular Homeostasis Positive Regulation Of Protein Export From Nucleus Regulation Of Catalytic Activity Protein Stabilization Chaperone-mediated Autophagy Aggresome Assembly Cellular Response To Mechanical Stimulus Chaperone-mediated Protein Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Transport Along Microtubule Regulation Of Cellular Response To Heat Negative Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Aggrephagy
Pathways			Regulation of HSF1-mediated heat shock response
Drugs		ATP Debromohymenialdisine
Diseases
GWAS		Bronchopulmonary dysplasia ( 23897914) Low density lipoprotein cholesterol levels ( 30498476) Total cholesterol levels ( 30498476)	Diastolic blood pressure ( 27841878) Heart failure ( 31919418) Idiopathic dilated cardiomyopathy ( 21459883) Parkinson's disease ( 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		45 interacting genes: AKT1 AQP1 AR ARSL BAG3 CDC42 CLTC CSPG4 CTTN EGFR FGFR1 FYN GALT GRB2 HCK HECW1 HSH2D HSP90AB2P ITFG2 KCNA5 KRTAP10-3 MAGI3 MCF2 MERTK NCK1 NEK6 NOTCH2NLA NPHP1 PDGFRB RASGEF1C RASGRF1 RPL18A SEZ6 SH2D1A SIAH1 SMURF1 SNX9 SOCS4 SRC SRSF5 VTI1B WAS WWOX WWP2 YES1	25 interacting genes: ACD ARRDC3 BCL2 CRYAB DAZAP2 DVL2 DYNLT1 FAM189A2 FBXO7 HSPA1A HSPA8 HSPB1 HSPB8 LITAF LRRK1 LRRK2 MAGED1 PDE9A PLCG1 POT1 SF3B4 SRPK2 TINF2 TNK2 WNK1
Entrez ID		10188	9531
HPRD ID		06104	04860
Ensembl ID		ENSG00000061938	ENSG00000151929
Uniprot IDs		A0A499FJ16 A0A5F9ZGX5 A0A5F9ZHJ2 B3KXJ4 C9J1X3 Q07912	O95817
PDB IDs		1CF4 1U46 1U4D 1U54 3EQP 3EQR 4EWH 4HZR 4HZS 4ID7 5ZXB
Enriched GO Terms of Interacting Partners?
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