BAG3 and DYNLT1

Number of citations of the paper that reports this interaction (PubMedID 21252941)
120

Data Source:
BioGRID (pull down, biochemical)

		BAG3	DYNLT1
Description		BAG cochaperone 3	dynein light chain Tctex-type 1
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cell Nucleus Cytoplasm Cytosol Plasma Membrane Aggresome Z Disc Neuron Projection Chaperone Complex	Extracellular Region Cell Mitochondrion Golgi Apparatus Spindle Cytoplasmic Dynein Complex Cytoplasmic Microtubule Lamellipodium Secretory Granule Lumen Neuronal Cell Body Host Cell Axonal Growth Cone Secretory Vesicle Ficolin-1-rich Granule Lumen
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding Protein-containing Complex Binding Cadherin Binding Dynein Intermediate Chain Binding Chaperone Binding	Motor Activity Protein Binding Protein C-terminus Binding Identical Protein Binding
	Biological Process	Autophagosome Assembly Protein Folding Brain Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Striated Muscle Cell Apoptotic Process Spinal Cord Development Cellular Response To Heat Cellular Response To Unfolded Protein Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Muscle Cell Cellular Homeostasis Positive Regulation Of Protein Export From Nucleus Regulation Of Catalytic Activity Protein Stabilization Chaperone-mediated Autophagy Aggresome Assembly Cellular Response To Mechanical Stimulus Chaperone-mediated Protein Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Transport Along Microtubule Regulation Of Cellular Response To Heat Negative Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Aggrephagy	Establishment Of Mitotic Spindle Orientation Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development Dendrite Development Intracellular Transport Of Viral Protein In Host Cell Positive Regulation Of Rac Protein Signal Transduction Negative Regulation Of Mitochondrial Membrane Permeability Regulation Of GTPase Activity Neutrophil Degranulation Viral Entry Into Host Cell Neuron Projection Morphogenesis Negative Regulation Of Neurogenesis Cell Division Regulation Of Cytoskeleton Organization Negative Regulation Of Cell Death Axon Development Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus
Pathways		Regulation of HSF1-mediated heat shock response	Neutrophil degranulation
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Heart failure ( 31919418) Idiopathic dilated cardiomyopathy ( 21459883) Parkinson's disease ( 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		25 interacting genes: ACD ARRDC3 BCL2 CRYAB DAZAP2 DVL2 DYNLT1 FAM189A2 FBXO7 HSPA1A HSPA8 HSPB1 HSPB8 LITAF LRRK1 LRRK2 MAGED1 PDE9A PLCG1 POT1 SF3B4 SRPK2 TINF2 TNK2 WNK1	26 interacting genes: APP BAG3 BMPR2 DDX54 DHX33 DOC2A DOC2B DVL1 DVL2 DYNC1I1 FXR2 HAVCR1 HSPB9 ILF2 KIF2A NUP153 NUP62 PVR RAD21 RBM14 SVIL TROAP TUBA3C TXN VDAC1 XRN2
Entrez ID		9531	6993
HPRD ID		04860	15987
Ensembl ID		ENSG00000151929	ENSG00000146425
Uniprot IDs		O95817	P63172
PDB IDs			5JPW
Enriched GO Terms of Interacting Partners?
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