TNK2 and WWP2

Number of citations of the paper that reports this interaction (PubMedID 19144635)
27

Data Source:
BioGRID (pull down)

		TNK2	WWP2
Description		tyrosine kinase non receptor 2	WW domain containing E3 ubiquitin protein ligase 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Plasma Membrane Clathrin-coated Pit Adherens Junction Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm Grb2-EGFR Complex Cytoophidium	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity GTPase Inhibitor Activity Signaling Receptor Binding Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding WW Domain Binding	RNA Polymerase II Transcription Factor Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Endocytosis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Small GTPase Mediated Signal Transduction Phosphorylation Cell Differentiation Negative Regulation Of GTPase Activity Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Clathrin-dependent Endocytosis	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Extracellular Transport Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Viral Entry Into Host Cell Negative Regulation Of Protein Transport Protein Autoubiquitination Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity
Pathways			Regulation of PTEN stability and activity NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs		ATP Debromohymenialdisine
Diseases
GWAS		Bronchopulmonary dysplasia ( 23897914) Low density lipoprotein cholesterol levels ( 30498476) Total cholesterol levels ( 30498476)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body mass index ( 26426971) Diastolic blood pressure ( 30578418) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Hand grip strength ( 29691431) Height ( 28552196 31562340) IgE levels ( 23146381) Knee osteoarthritis ( 30374069) Lung function (FVC) ( 30804560) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Menarche (age at onset) ( 25231870) Plantar fascial disorders ( 29534260) Pulse pressure ( 30578418) Smoking behaviour (cigarette pack-years) ( 30679032) Triglycerides ( 30275531)
Interacting Genes		45 interacting genes: AKT1 AQP1 AR ARSL BAG3 CDC42 CLTC CSPG4 CTTN EGFR FGFR1 FYN GALT GRB2 HCK HECW1 HSH2D HSP90AB2P ITFG2 KCNA5 KRTAP10-3 MAGI3 MCF2 MERTK NCK1 NEK6 NOTCH2NLA NPHP1 PDGFRB RASGEF1C RASGRF1 RPL18A SEZ6 SH2D1A SIAH1 SMURF1 SNX9 SOCS4 SRC SRSF5 VTI1B WAS WWOX WWP2 YES1	60 interacting genes: ANKRD44 ARRDC1 ATN1 CDC34 CLCN5 CPSF6 DAG1 DIDO1 EGR2 EWSR1 FAM189A2 FBXL18 GRAP2 HNRNPUL1 IL2RG IL6R LGALS9B NDFIP2 NUTF2 PAIP1 PDLIM7 PSMF1 PTEN RASA1 RNF11 RUSC1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SEC24D SF1 SFTPC SMAD3 SMAD7 SNRPC SPART TFAP2A TNK2 TP53BP2 TP73 TRAF4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2I UBE2J2 UBE2K UBE2L3 USP7 VASP VPS37C WBP1 WBP2 WIPF1 ZNF688
Entrez ID		10188	11060
HPRD ID		06104	03812
Ensembl ID		ENSG00000061938	ENSG00000198373
Uniprot IDs		A0A499FJ16 A0A5F9ZGX5 A0A5F9ZHJ2 B3KXJ4 C9J1X3 Q07912	A0A024R711 B4DHF6 O00308
PDB IDs		1CF4 1U46 1U4D 1U54 3EQP 3EQR 4EWH 4HZR 4HZS 4ID7 5ZXB	4Y07 5TJ7 5TJ8 5TJQ 6J1Z 6RSS
Enriched GO Terms of Interacting Partners?
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