BAG3 and PDE9A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		BAG3	PDE9A
Description		BAG cochaperone 3	phosphodiesterase 9A
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cell Nucleus Cytoplasm Cytosol Plasma Membrane Aggresome Z Disc Neuron Projection Chaperone Complex	Endoplasmic Reticulum Golgi Apparatus Cytosol Ruffle Membrane Sarcolemma Perikaryon Perinuclear Region Of Cytoplasm
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding Protein-containing Complex Binding Cadherin Binding Dynein Intermediate Chain Binding Chaperone Binding	3',5'-cyclic-nucleotide Phosphodiesterase Activity Protein Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Autophagosome Assembly Protein Folding Brain Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Striated Muscle Cell Apoptotic Process Spinal Cord Development Cellular Response To Heat Cellular Response To Unfolded Protein Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Muscle Cell Cellular Homeostasis Positive Regulation Of Protein Export From Nucleus Regulation Of Catalytic Activity Protein Stabilization Chaperone-mediated Autophagy Aggresome Assembly Cellular Response To Mechanical Stimulus Chaperone-mediated Protein Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Transport Along Microtubule Regulation Of Cellular Response To Heat Negative Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Aggrephagy	Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy CGMP-mediated Signaling CGMP Metabolic Process CGMP Catabolic Process
Pathways		Regulation of HSF1-mediated heat shock response	cGMP effects
Drugs			Caffeine Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine 3-isobutyl-1-methyl-7H-xanthine Trapidil
Diseases
GWAS		Diastolic blood pressure ( 27841878) Heart failure ( 31919418) Idiopathic dilated cardiomyopathy ( 21459883) Parkinson's disease ( 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Perceived unattractiveness to mosquitoes ( 28199695)
Interacting Genes		25 interacting genes: ACD ARRDC3 BCL2 CRYAB DAZAP2 DVL2 DYNLT1 FAM189A2 FBXO7 HSPA1A HSPA8 HSPB1 HSPB8 LITAF LRRK1 LRRK2 MAGED1 PDE9A PLCG1 POT1 SF3B4 SRPK2 TINF2 TNK2 WNK1	20 interacting genes: BAG3 C9orf106 CLK1 CRY2 GORASP2 KRTAP10-3 KRTAP10-8 KRTAP4-2 KRTAP9-2 LAGE3 LMO2 NAA38 NOTCH2NLA PCNT PHYHIPL SULT1E1 TFAP4 TRIM32 TRPV6 UTP23
Entrez ID		9531	5152
HPRD ID		04860	09115
Ensembl ID		ENSG00000151929	ENSG00000160191
Uniprot IDs		O95817	A0A0S2Z475 A0A0S2Z4A3 A0A0S2Z4T6 O76083
PDB IDs			2HD1 2YY2 3DY8 3DYL 3DYN 3DYQ 3DYS 3JSI 3JSW 3K3E 3K3H 3N3Z 3QI3 3QI4 4E90 4G2J 4G2L 4GH6 4Y86 4Y87 4Y8C 6A3N
Enriched GO Terms of Interacting Partners?
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