ABI2 and VARS2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ABI2	VARS2
Description		abl interactor 2	valyl-tRNA synthetase 2, mitochondrial
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Adherens Junction Lamellipodium SCAR Complex Filopodium Tip Dendritic Spine	Mitochondrion Cytosol
	Molecular Function	DNA Binding Protein Binding Cytoskeletal Adaptor Activity SH3 Domain Binding Kinase Binding Ubiquitin Protein Ligase Binding Rac GTPase Binding Proline-rich Region Binding	Aminoacyl-tRNA Editing Activity Valine-tRNA Ligase Activity ATP Binding
	Biological Process	Cytoskeleton Organization Actin Polymerization Or Depolymerization Viral Process Cell Migration Rac Protein Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Dendritic Spine Morphogenesis Lens Fiber Cell Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	TRNA Aminoacylation For Protein Translation Valyl-tRNA Aminoacylation Aminoacyl-tRNA Metabolism Involved In Translational Fidelity
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Mitochondrial tRNA aminoacylation
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Butyrylcholinesterase levels ( 21862451) Diverticular disease ( 30177863) Subclinical atherosclerosis traits (other) ( 17903303) Trunk fat mass ( 28552196) Urinary albumin-to-creatinine ratio ( 31511532)	Autism spectrum disorder or schizophrenia ( 28540026) Conotruncal heart defects (maternal effects) ( 28468790) Gestational age at birth (maternal effect) ( 28877031) HIV-1 control ( 20041166) Microalbuminuria in type 1 diabetes ( 31537649) Pubertal anthropometrics ( 23449627) Squamous cell lung carcinoma ( 28604730) Ulcerative colitis ( 20848476) Urate levels ( 31578528)
Interacting Genes		61 interacting genes: ABL1 ADAM19 ARHGAP32 ARMC7 BLOC1S6 CCDC102B CCHCR1 CDK6 CRX DTNB EFS EGLN3 EIF3H ENAH GCC1 HGS HNRNPK HOMER3 IFT20 IHO1 KHDRBS1 KIAA1217 KIFC3 KRT13 KRT15 KRT19 KRT20 KRT31 KRT33B LMO2 MCM7 MRFAP1L1 MRPL44 NCK1 NCK2 NUP62 PCM1 PIN1 PPIF PRAM1 PRKAA1 PRKAA2 PRR16 SDCBP SH3KBP1 SMARCB1 SNAP23 STAM2 TFIP11 TLE5 TRAF3IP1 TRIM32 TRIP6 VARS2 VASP VCL VPS37C WASF2 WASHC3 WIPF1 ZNF688	6 interacting genes: ABI2 CMTM5 MAL2 NCK2 PIK3CA SORBS3
Entrez ID		10152	57176
HPRD ID		07338	11670
Ensembl ID		ENSG00000138443	ENSG00000137411
Uniprot IDs		A0A0C4DG21 B7Z836 E9PEZ7 F8WAL6 Q9NYB9	A0A1U9X9B3 B4DG77 B4E0K6 Q5ST30
PDB IDs		2ED0 3P8C 4N78
Enriched GO Terms of Interacting Partners?
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