ABI2 and ADAM19

Number of citations of the paper that reports this interaction (PubMedID 12463424)
1

Data Source:
BioGRID (two hybrid, pull down)

		ABI2	ADAM19
Description		abl interactor 2	ADAM metallopeptidase domain 19
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Adherens Junction Lamellipodium SCAR Complex Filopodium Tip Dendritic Spine	Nucleus Golgi Apparatus Plasma Membrane Integral Component Of Membrane Collagen-containing Extracellular Matrix
	Molecular Function	DNA Binding Protein Binding Cytoskeletal Adaptor Activity SH3 Domain Binding Kinase Binding Ubiquitin Protein Ligase Binding Rac GTPase Binding Proline-rich Region Binding	Metalloendopeptidase Activity Protein Binding SH3 Domain Binding Metal Ion Binding
	Biological Process	Cytoskeleton Organization Actin Polymerization Or Depolymerization Viral Process Cell Migration Rac Protein Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Dendritic Spine Morphogenesis Lens Fiber Cell Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Placenta Development Membrane Protein Ectodomain Proteolysis Positive Regulation Of Gene Expression Extracellular Matrix Organization Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Invadopodia formation
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Butyrylcholinesterase levels ( 21862451) Diverticular disease ( 30177863) Subclinical atherosclerosis traits (other) ( 17903303) Trunk fat mass ( 28552196) Urinary albumin-to-creatinine ratio ( 31511532)	Blood protein levels ( 30072576) Body mass index ( 28552196) Chronic obstructive pulmonary disease ( 28166215 30804561) FEV1 ( 30804560) Inflammatory skin disease ( 25574825) Lung function (FEV1/FVC) ( 28166213 30804560) Medication use (adrenergics, inhalants) ( 31015401) Peak expiratory flow ( 30804560) Pulmonary function ( 20010835) Pulmonary function (smoking interaction) ( 23284291) Triglyceride levels ( 31647587)
Interacting Genes		61 interacting genes: ABL1 ADAM19 ARHGAP32 ARMC7 BLOC1S6 CCDC102B CCHCR1 CDK6 CRX DTNB EFS EGLN3 EIF3H ENAH GCC1 HGS HNRNPK HOMER3 IFT20 IHO1 KHDRBS1 KIAA1217 KIFC3 KRT13 KRT15 KRT19 KRT20 KRT31 KRT33B LMO2 MCM7 MRFAP1L1 MRPL44 NCK1 NCK2 NUP62 PCM1 PIN1 PPIF PRAM1 PRKAA1 PRKAA2 PRR16 SDCBP SH3KBP1 SMARCB1 SNAP23 STAM2 TFIP11 TLE5 TRAF3IP1 TRIM32 TRIP6 VARS2 VASP VCL VPS37C WASF2 WASHC3 WIPF1 ZNF688	7 interacting genes: A2M ABI2 COPB1 FURIN NRG1 SH3GL2 TNFSF11
Entrez ID		10152	8728
HPRD ID		07338	04704
Ensembl ID		ENSG00000138443	ENSG00000135074
Uniprot IDs		A0A0C4DG21 B7Z836 E9PEZ7 F8WAL6 Q9NYB9	Q8TBU7 Q9H013
PDB IDs		2ED0 3P8C 4N78
Enriched GO Terms of Interacting Partners?
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