ABI2 and SH3KBP1

Number of citations of the paper that reports this interaction (PubMedID 10858458)
35

Data Source:
HPRD (two hybrid, in vivo)

		ABI2	SH3KBP1
Description		abl interactor 2	SH3 domain containing kinase binding protein 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Adherens Junction Lamellipodium SCAR Complex Filopodium Tip Dendritic Spine	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Endocytic Vesicle Cytoplasmic Vesicle Membrane Neuron Projection Synapse
	Molecular Function	DNA Binding Protein Binding Cytoskeletal Adaptor Activity SH3 Domain Binding Kinase Binding Ubiquitin Protein Ligase Binding Rac GTPase Binding Proline-rich Region Binding	Protein Binding SH3 Domain Binding
	Biological Process	Cytoskeleton Organization Actin Polymerization Or Depolymerization Viral Process Cell Migration Rac Protein Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Dendritic Spine Morphogenesis Lens Fiber Cell Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Endocytosis Apoptotic Process Cytoskeleton Organization Actin Filament Organization Cell-cell Signaling Axon Guidance Regulation Of Cell Shape Cell Migration Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of B Cell Activation Membrane Organization
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Reelin signalling pathway InlB-mediated entry of Listeria monocytogenes into host cell Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Butyrylcholinesterase levels ( 21862451) Diverticular disease ( 30177863) Subclinical atherosclerosis traits (other) ( 17903303) Trunk fat mass ( 28552196) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		61 interacting genes: ABL1 ADAM19 ARHGAP32 ARMC7 BLOC1S6 CCDC102B CCHCR1 CDK6 CRX DTNB EFS EGLN3 EIF3H ENAH GCC1 HGS HNRNPK HOMER3 IFT20 IHO1 KHDRBS1 KIAA1217 KIFC3 KRT13 KRT15 KRT19 KRT20 KRT31 KRT33B LMO2 MCM7 MRFAP1L1 MRPL44 NCK1 NCK2 NUP62 PCM1 PIN1 PPIF PRAM1 PRKAA1 PRKAA2 PRR16 SDCBP SH3KBP1 SMARCB1 SNAP23 STAM2 TFIP11 TLE5 TRAF3IP1 TRIM32 TRIP6 VARS2 VASP VCL VPS37C WASF2 WASHC3 WIPF1 ZNF688	44 interacting genes: ABI2 ARAP3 ARHGAP27 ASAP1 ASAP2 BCAR1 BLNK BMPR1B CAPZA1 CBL CBLB CD2 GRB2 HCK INPP5D ITSN2 MVB12A NEDD4 PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 PSMA3 SEPTIN2 SEPTIN6 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SYNJ1 TAF6 TJP2 UBB UBC UBE2I ZBTB7B ZNF219
Entrez ID		10152	30011
HPRD ID		07338	02301
Ensembl ID		ENSG00000138443	ENSG00000147010
Uniprot IDs		A0A0C4DG21 B7Z836 E9PEZ7 F8WAL6 Q9NYB9	B7Z6E8 Q5JPT6 Q96B97
PDB IDs		2ED0 3P8C 4N78	2BZ8 2K6D 2K9G 2N64 2O2O 2YDL 5ABS
Enriched GO Terms of Interacting Partners?
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