SH3KBP1 and ASAP1

Number of citations of the paper that reports this interaction (PubMedID 15719014)
65

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SH3KBP1	ASAP1
Description		SH3 domain containing kinase binding protein 1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Endocytic Vesicle Cytoplasmic Vesicle Membrane Neuron Projection Synapse	Podosome Cytosol Cell Projection Membrane Dendritic Spine
	Molecular Function	Protein Binding SH3 Domain Binding	Phosphatidylserine Binding GTPase Activator Activity Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Cadherin Binding Metal Ion Binding
	Biological Process	Endocytosis Apoptotic Process Cytoskeleton Organization Actin Filament Organization Cell-cell Signaling Axon Guidance Regulation Of Cell Shape Cell Migration Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of B Cell Activation Membrane Organization	Positive Regulation Of GTPase Activity Cilium Assembly Negative Regulation Of Dendritic Spine Development Positive Regulation Of Podosome Assembly Positive Regulation Of Membrane Tubulation
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Reelin signalling pathway InlB-mediated entry of Listeria monocytogenes into host cell Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS			Diisocyanate-induced asthma ( 25918132) Mean platelet volume ( 27863252) Multiple sclerosis ( 19525955) Platelet count ( 27863252) Post bronchodilator FEV1 in COPD ( 26634245) Progressive supranuclear palsy ( 30089514) Tuberculosis ( 25774636) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		44 interacting genes: ABI2 ARAP3 ARHGAP27 ASAP1 ASAP2 BCAR1 BLNK BMPR1B CAPZA1 CBL CBLB CD2 GRB2 HCK INPP5D ITSN2 MVB12A NEDD4 PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 PSMA3 SEPTIN2 SEPTIN6 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SYNJ1 TAF6 TJP2 UBB UBC UBE2I ZBTB7B ZNF219	14 interacting genes: ARF1 ARF6 CBL CRK GRB2 HCK PACSIN3 PTK2 PTK2B PXN RAB11FIP3 REPS2 SH3KBP1 SRC
Entrez ID		30011	50807
HPRD ID		02301	05809
Ensembl ID		ENSG00000147010	ENSG00000153317
Uniprot IDs		B7Z6E8 Q5JPT6 Q96B97	A0A0A0MRE5 Q9ULH1
PDB IDs		2BZ8 2K6D 2K9G 2N64 2O2O 2YDL 5ABS	2D1X 2DA0 2ED1 2RQT 2RQU
Enriched GO Terms of Interacting Partners?
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