TOM1L1 and NDC80

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TOM1L1	NDC80
Description		target of myb1 like 1 membrane trafficking protein	NDC80 kinetochore complex component
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GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Golgi Stack Cytosol Endosome Membrane Extracellular Exosome	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Cell Nucleus Nucleoplasm Centrosome Cytosol Membrane Ndc80 Complex
	Molecular Function	Protein Binding SH3 Domain Binding Protein Kinase Binding Clathrin Binding Protein Kinase Activator Activity Ubiquitin Binding	Protein Binding Identical Protein Binding
	Biological Process	Intracellular Protein Transport Signal Transduction Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Mitotic Nuclear Division Regulation Of DNA Biosynthetic Process	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Cell Division Metaphase Plate Congression Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Protein Localization To Kinetochore
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965)	Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)
Interacting Genes		28 interacting genes: AMFR CCDC47 CELF1 COPS7A CWF19L1 FYN GLUD2 GRB2 GSN HGS HNRNPH1 MAP3K3 NDC80 NOMO1 PDPN PELP1 PHYH PIK3R1 PWP2 RAB18 TASOR TOLLIP TSG101 TUBA1B UBC UBXN4 VAV2 VCP	46 interacting genes: AMOTL2 ATF4 ATP5PO AURKA AURKB BLOC1S6 CALCOCO1 CCHCR1 CCNH CCNK CENPH CKAP5 HAUS1 HGS IFT20 INPP1 KLC3 KLHL12 KRT6B MAD1L1 MAD2L1 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PCM1 PFDN1 PSMC2 RB1 RUFY4 SFR1 SGF29 SKA1 SMC1A SPC25 STX11 TFIP11 TNIP1 TOM1L1 TP53BP2 TXLNA USHBP1 WASHC3 ZWINT
Entrez ID		10040	10403
HPRD ID		05266	06277
Ensembl ID		ENSG00000141198	ENSG00000080986
Uniprot IDs		O75674 Q8NI65	A8K031 O14777
PDB IDs		3RRU	2IGP 2VE7 3IZ0
Enriched GO Terms of Interacting Partners?
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