NPM1 and ABCC1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NPM1	ABCC1
Gene Name		nucleophosmin (nucleolar phosphoprotein B23, numatrin)	ATP-binding cassette, sub-family C (CFTR/MRP), member 1
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Focal Adhesion Membrane Ribonucleoprotein Complex Spindle Pole Centrosome	Plasma Membrane Integral Component Of Plasma Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	Transcription Coactivator Activity RNA Binding Protein Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Tat Protein Binding Histone Binding Protein Homodimerization Activity Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding Poly(A) RNA Binding Protein Heterodimerization Activity NF-kappaB Binding Unfolded Protein Binding	Transporter Activity ATP Binding ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances
	Biological Process	DNA Repair Nucleosome Assembly Intracellular Protein Transport Nucleocytoplasmic Transport Response To Stress Centrosome Cycle Signal Transduction Cell Aging Protein Localization Negative Regulation Of Cell Proliferation Negative Regulation Of Centrosome Duplication Viral Process Regulation Of Endodeoxyribonuclease Activity CENP-A Containing Nucleosome Assembly Ribosome Assembly Negative Regulation Of Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Translation Regulation Of Centriole Replication Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA	Leukotriene Metabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Transport Cobalamin Metabolic Process Arachidonic Acid Metabolic Process Response To Drug Small Molecule Metabolic Process Transmembrane Transport
Pathways		Chromosome Maintenance Nucleosome assembly HIV Infection Nuclear import of Rev protein Deposition of new CENPA-containing nucleosomes at the centromere Host Interactions of HIV factors Interactions of Rev with host cellular proteins	Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF ABC-family proteins mediated transport Metabolism of lipids and lipoproteins Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Arachidonic acid metabolism Defective AMN causes hereditary megaloblastic anemia 1 Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Synthesis of Leukotrienes (LT) and Eoxins (EX) Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism
Drugs			Sulfinpyrazone
Diseases
GWAS
Protein-Protein Interactions		53 interactors: ABCC1 ACY1 ALK APP ARF1 CDK1 CDK2 CDKN1A CDT1 COX8A CSNK2A1 EIF2AK2 EIF3E ELF4 EP300 ERG GADD45A GNAI2 GRB2 GZMM HAND2 HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST3H3 HMGA1 HMGA2 HOXA7 IRF1 IRS1 MDM2 NCL NOP2 NPM2 PADI4 PARP1 PLCG1 PLCG2 PLK1 PSMC4 RELA RPGR SENP3 SHC1 SREK1 TCERG1 TFAP2A TP53 UQCRH USP36 XPO1 YY1	3 interactors: AZGP1 NPM1 TRAF3
Entrez ID		4869	4363
HPRD ID		01246	01153
Ensembl ID		ENSG00000181163	ENSG00000103222
Uniprot IDs		P06748	P33527
PDB IDs		2LLH 2P1B 2VXD	2CBZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Innate Immune Response Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Cell Cycle Checkpoint Mitotic Cell Cycle Checkpoint Regulation Of Gene Expression Immune System Process Response To Stress Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Immune Response Regulation Of Mitotic Cell Cycle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Positive Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Mitotic DNA Damage Checkpoint DNA Damage Checkpoint Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Metabolic Process Mitotic DNA Integrity Checkpoint Cellular Response To DNA Damage Stimulus Negative Regulation Of Cell Cycle Chromosome Organization Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Nitrogen Compound Metabolic Process Mitotic Cell Cycle Regulation Of Transcription, DNA-templated DNA Packaging Nucleobase-containing Compound Metabolic Process Fc Receptor Signaling Pathway Regulation Of Cell Proliferation Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Stress Cellular Nitrogen Compound Metabolic Process	Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of Ribonuclease Activity Regulation Of Endodeoxyribonuclease Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Toll Signaling Pathway Regulation Of Centriole Replication Negative Regulation Of Centrosome Duplication Positive Regulation Of Immune Response Negative Regulation Of Cell Proliferation CENP-A Containing Nucleosome Assembly Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Ribosome Assembly Regulation Of Immune Response Sensory Perception Of Bitter Taste Tumor Necrosis Factor-mediated Signaling Pathway Histone Exchange Positive Regulation Of Immune System Process DNA Replication-independent Nucleosome Assembly Detection Of Chemical Stimulus Involved In Sensory Perception Of Taste Cellular Response To DsRNA Regulation Of Interferon-beta Production Regulation Of Centrosome Duplication Negative Regulation Of Type I Interferon Production Regulation Of Centrosome Cycle Centromere Complex Assembly Centrosome Cycle Protein Transmembrane Transport Retina Homeostasis Negative Regulation Of NF-kappaB Transcription Factor Activity TRIF-dependent Toll-like Receptor Signaling Pathway Sensory Perception Of Taste MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response ATP-dependent Chromatin Remodeling Regulation Of Immune System Process Cell Aging Response To DsRNA Positive Regulation Of Translation Regulation Of Defense Response To Virus Toll-like Receptor 4 Signaling Pathway Protein Transport Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Apoptotic Process Establishment Of Protein Localization Regulation Of Cell Proliferation Regulation Of T Cell Mediated Cytotoxicity Regulation Of Cell Death
Tagcloud ?		aggressive aml amplicon consecutive counterparts covering de expands flt3 frequent heterogeneous hotspots illumina mds mutated myeloid neoplasms next novo panel prevalent profile profiling ptpn11 similarly summary syndromes tp53 truseq	abcb1 abcb5 abcb8 abcc3 abcc5 abcg2 bcrp canine cassette cytostatic demographics dogs doxorubicin efflux glucocorticoids hypercalcaemia lymphoma lymphomas mrp1 multicentric multidrug protocol quantified staging substage transporter tumour typically
Tagcloud (Difference) ?		aggressive aml amplicon consecutive counterparts covering de expands flt3 frequent heterogeneous hotspots illumina mds mutated myeloid neoplasms next novo panel prevalent profile profiling ptpn11 similarly summary syndromes tp53 truseq	abcb1 abcb5 abcb8 abcc3 abcc5 abcg2 bcrp canine cassette cytostatic demographics dogs doxorubicin efflux glucocorticoids hypercalcaemia lymphoma lymphomas mrp1 multicentric multidrug protocol quantified staging substage transporter tumour typically
Tagcloud (Intersection) ?