NPM1 and NPM2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		NPM1	NPM2
Gene Name		nucleophosmin (nucleolar phosphoprotein B23, numatrin)	nucleophosmin/nucleoplasmin 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Focal Adhesion Membrane Ribonucleoprotein Complex Spindle Pole Centrosome	Cytoplasmic Chromatin Nuclear Chromatin Nucleus
	Molecular Function	Transcription Coactivator Activity RNA Binding Protein Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Tat Protein Binding Histone Binding Protein Homodimerization Activity Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding Poly(A) RNA Binding Protein Heterodimerization Activity NF-kappaB Binding Unfolded Protein Binding	Nucleic Acid Binding Chromatin Binding Enzyme Binding Histone Binding
	Biological Process	DNA Repair Nucleosome Assembly Intracellular Protein Transport Nucleocytoplasmic Transport Response To Stress Centrosome Cycle Signal Transduction Cell Aging Protein Localization Negative Regulation Of Cell Proliferation Negative Regulation Of Centrosome Duplication Viral Process Regulation Of Endodeoxyribonuclease Activity CENP-A Containing Nucleosome Assembly Ribosome Assembly Negative Regulation Of Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Translation Regulation Of Centriole Replication Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA	Chromatin Remodeling Regulation Of Exit From Mitosis Single Fertilization Embryo Development Oocyte Differentiation Positive Regulation Of Catalytic Activity Positive Regulation Of DNA Replication Positive Regulation Of Meiotic Nuclear Division Protein Homooligomerization
Pathways		Chromosome Maintenance Nucleosome assembly HIV Infection Nuclear import of Rev protein Deposition of new CENPA-containing nucleosomes at the centromere Host Interactions of HIV factors Interactions of Rev with host cellular proteins
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		53 interactors: ABCC1 ACY1 ALK APP ARF1 CDK1 CDK2 CDKN1A CDT1 COX8A CSNK2A1 EIF2AK2 EIF3E ELF4 EP300 ERG GADD45A GNAI2 GRB2 GZMM HAND2 HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST3H3 HMGA1 HMGA2 HOXA7 IRF1 IRS1 MDM2 NCL NOP2 NPM2 PADI4 PARP1 PLCG1 PLCG2 PLK1 PSMC4 RELA RPGR SENP3 SHC1 SREK1 TCERG1 TFAP2A TP53 UQCRH USP36 XPO1 YY1	5 interactors: NPM1 NPM3 PLEKHF2 SDCBP2 SRPK2
Entrez ID		4869	10361
HPRD ID		01246	12160
Ensembl ID		ENSG00000181163	ENSG00000158806
Uniprot IDs		P06748	Q6NVH6 Q86SE8
PDB IDs		2LLH 2P1B 2VXD	3T30
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Innate Immune Response Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Cell Cycle Checkpoint Mitotic Cell Cycle Checkpoint Regulation Of Gene Expression Immune System Process Response To Stress Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Immune Response Regulation Of Mitotic Cell Cycle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Positive Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Mitotic DNA Damage Checkpoint DNA Damage Checkpoint Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Metabolic Process Mitotic DNA Integrity Checkpoint Cellular Response To DNA Damage Stimulus Negative Regulation Of Cell Cycle Chromosome Organization Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Nitrogen Compound Metabolic Process Mitotic Cell Cycle Regulation Of Transcription, DNA-templated DNA Packaging Nucleobase-containing Compound Metabolic Process Fc Receptor Signaling Pathway Regulation Of Cell Proliferation Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Stress Cellular Nitrogen Compound Metabolic Process	Ribonucleoprotein Complex Biogenesis Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Nuclear Speck Organization Ribonucleoprotein Complex Assembly Regulation Of Ribonuclease Activity Regulation Of Endodeoxyribonuclease Activity Ribosome Biogenesis Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Centriole Replication Negative Regulation Of Centrosome Duplication
Tagcloud ?		aggressive aml amplicon consecutive counterparts covering de expands flt3 frequent heterogeneous hotspots illumina mds mutated myeloid neoplasms next novo panel prevalent profile profiling ptpn11 similarly summary syndromes tp53 truseq	autoantigenic chaperones dramatic egg embryogenesis evolutionarily evolutionary evolved fertilization genuine h2a h2b histones monophyletic nasp npm3 nucleoplasmin paternal plethora ptms recurrently reviews revolves somatic sperm storage takes taxa
Tagcloud (Difference) ?		aggressive aml amplicon consecutive counterparts covering de expands flt3 frequent heterogeneous hotspots illumina mds mutated myeloid neoplasms next novo panel prevalent profile profiling ptpn11 similarly summary syndromes tp53 truseq	autoantigenic chaperones dramatic egg embryogenesis evolutionarily evolutionary evolved fertilization genuine h2a h2b histones monophyletic nasp npm3 nucleoplasmin paternal plethora ptms recurrently reviews revolves somatic sperm storage takes taxa
Tagcloud (Intersection) ?