NPM1 and TCERG1

Number of citations of the paper that reports this interaction (PMID 15456888)
27

Data Source:
HPRD (in vitro)

		NPM1	TCERG1
Gene Name		nucleophosmin (nucleolar phosphoprotein B23, numatrin)	transcription elongation regulator 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Focal Adhesion Membrane Ribonucleoprotein Complex Spindle Pole Centrosome	Nucleus Nucleolus Actin Cytoskeleton
	Molecular Function	Transcription Coactivator Activity RNA Binding Protein Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Tat Protein Binding Histone Binding Protein Homodimerization Activity Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding Poly(A) RNA Binding Protein Heterodimerization Activity NF-kappaB Binding Unfolded Protein Binding	RNA Polymerase II Repressing Transcription Factor Binding RNA Polymerase II Transcription Corepressor Activity Transcription Coactivator Activity Protein Binding Poly(A) RNA Binding Proline-rich Region Binding
	Biological Process	DNA Repair Nucleosome Assembly Intracellular Protein Transport Nucleocytoplasmic Transport Response To Stress Centrosome Cycle Signal Transduction Cell Aging Protein Localization Negative Regulation Of Cell Proliferation Negative Regulation Of Centrosome Duplication Viral Process Regulation Of Endodeoxyribonuclease Activity CENP-A Containing Nucleosome Assembly Ribosome Assembly Negative Regulation Of Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Translation Regulation Of Centriole Replication Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter
Pathways		Chromosome Maintenance Nucleosome assembly HIV Infection Nuclear import of Rev protein Deposition of new CENPA-containing nucleosomes at the centromere Host Interactions of HIV factors Interactions of Rev with host cellular proteins
Drugs
Diseases
GWAS
Protein-Protein Interactions		53 interactors: ABCC1 ACY1 ALK APP ARF1 CDK1 CDK2 CDKN1A CDT1 COX8A CSNK2A1 EIF2AK2 EIF3E ELF4 EP300 ERG GADD45A GNAI2 GRB2 GZMM HAND2 HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST3H3 HMGA1 HMGA2 HOXA7 IRF1 IRS1 MDM2 NCL NOP2 NPM2 PADI4 PARP1 PLCG1 PLCG2 PLK1 PSMC4 RELA RPGR SENP3 SHC1 SREK1 TCERG1 TFAP2A TP53 UQCRH USP36 XPO1 YY1	52 interactors: ABI1 BARD1 BRD4 CHAF1A CHD3 CPSF6 CYFIP1 CYFIP2 DIAPH1 DIAPH2 DNAJB9 EVL FANCA FANCC FMNL1 GRB2 HNRNPH1 HNRNPK HNRNPM HNRNPU HSPA1A HSPA5 HSPA8 HTT JUNB LUC7L NONO NPM1 NUDT21 PCBP1 PIAS4 POLR2A PSPC1 SETDB1 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SRSF1 SUMO1 TPM4 U2AF2 WAS WASF2 WBP4 WIPF2 WWOX
Entrez ID		4869	10915
HPRD ID		01246	10393
Ensembl ID		ENSG00000181163	ENSG00000113649
Uniprot IDs		P06748	O14776
PDB IDs		2LLH 2P1B 2VXD	2DK7 2DOD 2DOE 2DOF 2E71 2KIQ 2KIS 2NNT 3HFH 4FQG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Innate Immune Response Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Cell Cycle Checkpoint Mitotic Cell Cycle Checkpoint Regulation Of Gene Expression Immune System Process Response To Stress Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Immune Response Regulation Of Mitotic Cell Cycle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Positive Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Mitotic DNA Damage Checkpoint DNA Damage Checkpoint Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Metabolic Process Mitotic DNA Integrity Checkpoint Cellular Response To DNA Damage Stimulus Negative Regulation Of Cell Cycle Chromosome Organization Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Nitrogen Compound Metabolic Process Mitotic Cell Cycle Regulation Of Transcription, DNA-templated DNA Packaging Nucleobase-containing Compound Metabolic Process Fc Receptor Signaling Pathway Regulation Of Cell Proliferation Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Stress Cellular Nitrogen Compound Metabolic Process	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Nitrogen Compound Metabolic Process MRNA 3'-splice Site Recognition Cellular Component Assembly MRNA Splice Site Selection Spliceosomal Complex Assembly Regulation Of RNA Splicing Cellular Macromolecular Complex Assembly Ribonucleoprotein Complex Assembly Cellular Metabolic Process Protein Complex Assembly Cellular Process Positive Regulation Of RNA Splicing Cellular Response To Stress Regulation Of MRNA Processing Actin Polymerization Or Depolymerization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cellular Response To DNA Damage Stimulus Response To Stress DNA Repair Ribonucleoprotein Complex Biogenesis Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Transcription, DNA-templated Viral Process Phagocytosis Regulation Of Gene Expression Fc Receptor Signaling Pathway RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process MRNA 3'-end Processing Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Lamellipodium Morphogenesis Rhythmic Process Developmental Process
Tagcloud ?		aggressive aml amplicon consecutive counterparts covering de expands flt3 frequent heterogeneous hotspots illumina mds mutated myeloid neoplasms next novo panel prevalent profile profiling ptpn11 similarly summary syndromes tp53 truseq	12p13 12q21 17q11 3q26 5q22 5q32 acgh bac balanced ccnd2 clonality cnas concordant cryptic cytogenetics emp1 evi1 evolving exploratory hidden imbalances karyotypically karyotyping kitlg nf1 platforms recurring submicroscopic unidentified
Tagcloud (Difference) ?		aggressive aml amplicon consecutive counterparts covering de expands flt3 frequent heterogeneous hotspots illumina mds mutated myeloid neoplasms next novo panel prevalent profile profiling ptpn11 similarly summary syndromes tp53 truseq	12p13 12q21 17q11 3q26 5q22 5q32 acgh bac balanced ccnd2 clonality cnas concordant cryptic cytogenetics emp1 evi1 evolving exploratory hidden imbalances karyotypically karyotyping kitlg nf1 platforms recurring submicroscopic unidentified
Tagcloud (Intersection) ?