NPM1 and COX8A

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		NPM1	COX8A
Gene Name		nucleophosmin (nucleolar phosphoprotein B23, numatrin)	cytochrome c oxidase subunit VIIIA (ubiquitous)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Focal Adhesion Membrane Ribonucleoprotein Complex Spindle Pole Centrosome	Mitochondrial Inner Membrane Integral Component Of Membrane
	Molecular Function	Transcription Coactivator Activity RNA Binding Protein Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Tat Protein Binding Histone Binding Protein Homodimerization Activity Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding Poly(A) RNA Binding Protein Heterodimerization Activity NF-kappaB Binding Unfolded Protein Binding	Cytochrome-c Oxidase Activity
	Biological Process	DNA Repair Nucleosome Assembly Intracellular Protein Transport Nucleocytoplasmic Transport Response To Stress Centrosome Cycle Signal Transduction Cell Aging Protein Localization Negative Regulation Of Cell Proliferation Negative Regulation Of Centrosome Duplication Viral Process Regulation Of Endodeoxyribonuclease Activity CENP-A Containing Nucleosome Assembly Ribosome Assembly Negative Regulation Of Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Translation Regulation Of Centriole Replication Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA	Generation Of Precursor Metabolites And Energy Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process Transmembrane Transport Hydrogen Ion Transmembrane Transport
Pathways		Chromosome Maintenance Nucleosome assembly HIV Infection Nuclear import of Rev protein Deposition of new CENPA-containing nucleosomes at the centromere Host Interactions of HIV factors Interactions of Rev with host cellular proteins	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport Orphan transporters
Drugs
Diseases
GWAS
Protein-Protein Interactions		53 interactors: ABCC1 ACY1 ALK APP ARF1 CDK1 CDK2 CDKN1A CDT1 COX8A CSNK2A1 EIF2AK2 EIF3E ELF4 EP300 ERG GADD45A GNAI2 GRB2 GZMM HAND2 HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST3H3 HMGA1 HMGA2 HOXA7 IRF1 IRS1 MDM2 NCL NOP2 NPM2 PADI4 PARP1 PLCG1 PLCG2 PLK1 PSMC4 RELA RPGR SENP3 SHC1 SREK1 TCERG1 TFAP2A TP53 UQCRH USP36 XPO1 YY1	2 interactors: AMBP NPM1
Entrez ID		4869	1351
HPRD ID		01246	00468
Ensembl ID		ENSG00000181163	ENSG00000176340
Uniprot IDs		P06748	P10176 Q53XN1
PDB IDs		2LLH 2P1B 2VXD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Innate Immune Response Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Cell Cycle Checkpoint Mitotic Cell Cycle Checkpoint Regulation Of Gene Expression Immune System Process Response To Stress Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Immune Response Regulation Of Mitotic Cell Cycle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Positive Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Mitotic DNA Damage Checkpoint DNA Damage Checkpoint Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Metabolic Process Mitotic DNA Integrity Checkpoint Cellular Response To DNA Damage Stimulus Negative Regulation Of Cell Cycle Chromosome Organization Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Nitrogen Compound Metabolic Process Mitotic Cell Cycle Regulation Of Transcription, DNA-templated DNA Packaging Nucleobase-containing Compound Metabolic Process Fc Receptor Signaling Pathway Regulation Of Cell Proliferation Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Stress Cellular Nitrogen Compound Metabolic Process	Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of Ribonuclease Activity Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Phosphorylation Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Viral Process Heme Catabolic Process Regulation Of Centriole Replication Negative Regulation Of Catalytic Activity Protein-chromophore Linkage Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Centrosome Duplication Negative Regulation Of Protein Metabolic Process CENP-A Containing Nucleosome Assembly Ribosome Assembly Negative Regulation Of JNK Cascade Histone Exchange DNA Replication-independent Nucleosome Assembly Negative Regulation Of Stress-activated MAPK Cascade Cellular Response To DsRNA Regulation Of Phosphorylation Heme Metabolic Process Regulation Of Centrosome Duplication Regulation Of Phosphorus Metabolic Process Regulation Of Centrosome Cycle Centromere Complex Assembly Porphyrin-containing Compound Metabolic Process Centrosome Cycle ATP-dependent Chromatin Remodeling Cell Aging Response To DsRNA Positive Regulation Of Translation Tetrapyrrole Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Centrosome Organization Regulation Of Protein Metabolic Process Microtubule Organizing Center Organization Nucleosome Assembly Regulation Of Catalytic Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Immune Response Chromatin Assembly Nucleosome Organization Regulation Of Microtubule Cytoskeleton Organization Chromatin Assembly Or Disassembly Negative Regulation Of MAPK Cascade Negative Regulation Of Cytoskeleton Organization Protein-DNA Complex Assembly
Tagcloud ?		aggressive aml amplicon consecutive counterparts covering de expands flt3 frequent heterogeneous hotspots illumina mds mutated myeloid neoplasms next novo panel prevalent profile profiling ptpn11 similarly summary syndromes tp53 truseq
Tagcloud (Difference) ?		aggressive aml amplicon consecutive counterparts covering de expands flt3 frequent heterogeneous hotspots illumina mds mutated myeloid neoplasms next novo panel prevalent profile profiling ptpn11 similarly summary syndromes tp53 truseq
Tagcloud (Intersection) ?