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NEK2 and SPTBN4
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
NEK2
SPTBN4
Gene Name
NIMA-related kinase 2
spectrin, beta, non-erythrocytic 4
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Kinetochore
Condensed Chromosome Kinetochore
Condensed Nuclear Chromosome
Spindle Pole
Nucleus
Nucleolus
Cytoplasm
Centrosome
Cytosol
Microtubule
Midbody
Protein Complex
Intercellular Bridge
Cytoplasm
Cytosol
Plasma Membrane
Adherens Junction
Spectrin
Membrane
Nuclear Matrix
PML Body
Node Of Ranvier
Paranode Region Of Axon
Neuronal Cell Body
Axon Initial Segment
Axon Hillock
Extracellular Vesicular Exosome
Cell Body Fiber
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Phosphatase Binding
Metal Ion Binding
Actin Binding
Structural Constituent Of Cytoskeleton
Protein Binding
Phospholipid Binding
Phosphatase Binding
Ankyrin Binding
Spectrin Binding
Biological Process
Mitotic Sister Chromatid Segregation
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Blastocyst Development
Protein Phosphorylation
Organelle Organization
Chromosome Segregation
Mitotic Nuclear Division
Regulation Of Mitotic Nuclear Division
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA Binding
Regulation Of Mitotic Centrosome Separation
Protein Autophosphorylation
Spindle Assembly
Centrosome Separation
Cell Division
Meiotic Cell Cycle
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Mitotic Spindle Assembly
Negative Regulation Of Centriole-centriole Cohesion
Regulation Of Sodium Ion Transport
Cytoskeletal Anchoring At Plasma Membrane
Axonogenesis
Axon Guidance
Sensory Perception Of Sound
Adult Walking Behavior
Fertilization
Negative Regulation Of Heart Rate
Vesicle-mediated Transport
Transmission Of Nerve Impulse
Central Nervous System Projection Neuron Axonogenesis
Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Multicellular Organism Growth
Clustering Of Voltage-gated Sodium Channels
Actin Filament Capping
Cardiac Conduction
Establishment Of Protein Localization To Plasma Membrane
Pathways
Organelle biogenesis and maintenance
APC/C:Cdc20 mediated degradation of mitotic proteins
Assembly of the primary cilium
G2/M Transition
Anchoring of the basal body to the plasma membrane
Regulation of PLK1 Activity at G2/M Transition
APC/C-mediated degradation of cell cycle proteins
Cell Cycle, Mitotic
Loss of proteins required for interphase microtubule organization from the centrosome
Loss of Nlp from mitotic centrosomes
Regulation of mitotic cell cycle
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Centrosome maturation
Mitotic G2-G2/M phases
Recruitment of mitotic centrosome proteins and complexes
Interaction between L1 and Ankyrins
Axon guidance
L1CAM interactions
NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS
Protein-Protein Interactions
23 interactors:
CCDC85A
CEP250
CHGA
CSN2
CTNNB1
DCTN1
EDRF1
EIF4A2
GIT1
IFT140
IMMT
MAD1L1
MAPK1
MCC
NDC80
NEK11
PDE4DIP
PPP1CA
PPP1CC
PPP1R2
SPTBN4
TCF25
TPM3
12 interactors:
ANK3
CDC37
CELSR3
CENPU
DISC1
GADD45A
GSK3B
NEK2
PFDN1
PTPRN
PTPRN2
RPS6KA6
Entrez ID
4751
57731
HPRD ID
04953
09372
Ensembl ID
ENSG00000117650
ENSG00000160460
Uniprot IDs
P51955
C9JY79
Q9H254
PDB IDs
2JAV
2W5A
2W5B
2W5H
2WQO
2XK3
2XK4
2XK6
2XK7
2XK8
2XKC
2XKD
2XKE
2XKF
2XNM
2XNN
2XNO
2XNP
4A4X
4AFE
Enriched GO Terms of Interacting Partners
?
Cell Cycle
Regulation Of Centriole-centriole Cohesion
Glycogen Metabolic Process
Mitotic Cell Cycle
Polysaccharide Metabolic Process
Regulation Of Organelle Organization
Triglyceride Catabolic Process
Entrainment Of Circadian Clock By Photoperiod
Movement Of Cell Or Subcellular Component
Cell Cycle Process
Photoperiodism
Entrainment Of Circadian Clock
Acylglycerol Catabolic Process
Energy Reserve Metabolic Process
Mitotic Cell Cycle Process
Microtubule-based Process
Cell Division
Regulation Of Cellular Response To Growth Factor Stimulus
Negative Regulation Of Mitotic Cell Cycle
Negative Regulation Of RNA-directed RNA Polymerase Activity
Regulation Of Metaphase Plate Congression
Regulation Of Cytoskeleton Organization
Cellular Protein Localization
Cellular Carbohydrate Metabolic Process
Centrosome Cycle
Cellular Response To Growth Factor Stimulus
MAPK Import Into Nucleus
Negative Regulation Of Mitotic Cell Cycle, Embryonic
Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Schwann Cell Proliferation
Cellular Response To Insulin-like Growth Factor Stimulus
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Response To Growth Factor
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Chromosome Segregation
Regulation Of Signal Transduction
Cell Morphogenesis
Circadian Regulation Of Gene Expression
Energy Derivation By Oxidation Of Organic Compounds
Response To Abiotic Stimulus
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation
Renal Inner Medulla Development
Renal Outer Medulla Development
Mesenchymal Cell Proliferation Involved In Lung Development
Glial Cell Fate Determination
Oviduct Development
Mitotic Nuclear Division
Neuron Differentiation
Establishment Of Organelle Localization
Cell Cycle
Organelle Organization
Axon Development
Cytoskeleton Organization
Locomotion
Regulation Of Cellular Process
Telencephalon Development
Centrosome Cycle
Nervous System Development
Regulation Of Protein Localization
Movement Of Cell Or Subcellular Component
Maintenance Of Protein Location In Plasma Membrane
Negative Regulation Of Centriole-centriole Cohesion
Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential
Neuron Projection Development
Multicellular Organismal Development
Cell Projection Morphogenesis
Cellular Response To Mechanical Stimulus
Generation Of Neurons
Cell Part Morphogenesis
Anatomical Structure Development
Axon Guidance
Neurogenesis
Negative Regulation Of Phosphorylation
Neuron Development
Signal Transduction In Response To DNA Damage
Negative Regulation Of Type B Pancreatic Cell Development
Positive Regulation Of Cell Communication By Electrical Coupling
Negative Regulation Of Delayed Rectifier Potassium Channel Activity
Superior Temporal Gyrus Development
Dense Core Granule Maturation
Canonical Wnt Signaling Pathway
Central Nervous System Development
Signal Transduction
Centrosome Organization
Negative Regulation Of Binding
Microtubule Cytoskeleton Organization
Forebrain Development
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Cell Cycle Process
Cell Morphogenesis
Microtubule Organizing Center Organization
Re-entry Into Mitotic Cell Cycle
Negative Regulation Of Neuron Maturation
Regulation Of Centriole-centriole Cohesion
Developmental Process
Protein Localization
Neuron Differentiation
Signaling
Cell Projection Organization
Tagcloud
?
called
complementary
cyclins
dissociated
dnas
ectopic
elucidate
eventually
g2
gst
hec
heptad
hydrolyzes
inhibits
interacts
leucine
mitosis
mitotic
modulate
mss1
p45
proteasome
proteolysis
pull
repeats
seventh
smc1
smc2
telophase
Tagcloud (Difference)
?
called
complementary
cyclins
dissociated
dnas
ectopic
elucidate
eventually
g2
gst
hec
heptad
hydrolyzes
inhibits
interacts
leucine
mitosis
mitotic
modulate
mss1
p45
proteasome
proteolysis
pull
repeats
seventh
smc1
smc2
telophase
Tagcloud (Intersection)
?