NEK2 and CEP250

Number of citations of the paper that reports this interaction (PMID 9647649)
89

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro, two hybrid)

		NEK2	CEP250
Gene Name		NIMA-related kinase 2	centrosomal protein 250kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleolus Cytoplasm Centrosome Cytosol Microtubule Midbody Protein Complex Intercellular Bridge	Centrosome Centriole Microtubule Organizing Center Cytosol Cilium Spindle Pole Centrosome Protein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding Metal Ion Binding	Protein Binding Protein C-terminus Binding Protein Kinase Binding Protein Domain Specific Binding
	Biological Process	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Blastocyst Development Protein Phosphorylation Organelle Organization Chromosome Segregation Mitotic Nuclear Division Regulation Of Mitotic Nuclear Division Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA Binding Regulation Of Mitotic Centrosome Separation Protein Autophosphorylation Spindle Assembly Centrosome Separation Cell Division Meiotic Cell Cycle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic Spindle Assembly Negative Regulation Of Centriole-centriole Cohesion	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Protein Localization Centriole-centriole Cohesion Regulation Of Centriole-centriole Cohesion Protein Localization To Organelle
Pathways		Organelle biogenesis and maintenance APC/C:Cdc20 mediated degradation of mitotic proteins Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes	Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS			Height ( 18391951) Ulcerative colitis ( 23128233)
Protein-Protein Interactions		23 interactors: CCDC85A CEP250 CHGA CSN2 CTNNB1 DCTN1 EDRF1 EIF4A2 GIT1 IFT140 IMMT MAD1L1 MAPK1 MCC NDC80 NEK11 PDE4DIP PPP1CA PPP1CC PPP1R2 SPTBN4 TCF25 TPM3	6 interactors: APP ATF7IP KAT2B NEK2 PLEKHA5 YWHAG
Entrez ID		4751	11190
HPRD ID		04953	09877
Ensembl ID		ENSG00000117650	ENSG00000126001
Uniprot IDs		P51955	Q9BV73
PDB IDs		2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP 4A4X 4AFE
Enriched GO Terms of Interacting Partners?		Cell Cycle Regulation Of Centriole-centriole Cohesion Glycogen Metabolic Process Mitotic Cell Cycle Polysaccharide Metabolic Process Regulation Of Organelle Organization Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Movement Of Cell Or Subcellular Component Cell Cycle Process Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Energy Reserve Metabolic Process Mitotic Cell Cycle Process Microtubule-based Process Cell Division Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of RNA-directed RNA Polymerase Activity Regulation Of Metaphase Plate Congression Regulation Of Cytoskeleton Organization Cellular Protein Localization Cellular Carbohydrate Metabolic Process Centrosome Cycle Cellular Response To Growth Factor Stimulus MAPK Import Into Nucleus Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Response To Growth Factor Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Chromosome Segregation Regulation Of Signal Transduction Cell Morphogenesis Circadian Regulation Of Gene Expression Energy Derivation By Oxidation Of Organic Compounds Response To Abiotic Stimulus Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Renal Inner Medulla Development Renal Outer Medulla Development Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination Oviduct Development Mitotic Nuclear Division Neuron Differentiation Establishment Of Organelle Localization	Negative Regulation Of Centriole-centriole Cohesion G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Serine/threonine Kinase Activity Histone H3-K9 Acetylation Regulation Of Protein ADP-ribosylation Synaptic Growth At Neuromuscular Junction Notch Signaling Pathway Regulation Of Protein Kinase Activity Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Collateral Sprouting In Absence Of Injury Regulation Of Centriole-centriole Cohesion N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Cellular Response To Insulin Stimulus Regulation Of Mitotic Centrosome Separation Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Chromosome Organization Cell Cycle Process Axon Choice Point Recognition Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Phosphorylation Regulation Of Binding Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Response To Insulin Neuron Remodeling Negative Regulation Of Transferase Activity Cellular Response To Peptide Hormone Stimulus Regulation Of Protein Glycosylation Negative Regulation Of Protein Phosphorylation Cellular Response To Peptide Regulation Of Phosphorylation N-terminal Protein Amino Acid Acetylation Positive Regulation Of Transcription, DNA-templated Cell Cycle Organelle Organization Centrosome Separation Negative Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process
Tagcloud ?		called complementary cyclins dissociated dnas ectopic elucidate eventually g2 gst hec heptad hydrolyzes inhibits interacts leucine mitosis mitotic modulate mss1 p45 proteasome proteolysis pull repeats seventh smc1 smc2 telophase
Tagcloud (Difference) ?		called complementary cyclins dissociated dnas ectopic elucidate eventually g2 gst hec heptad hydrolyzes inhibits interacts leucine mitosis mitotic modulate mss1 p45 proteasome proteolysis pull repeats seventh smc1 smc2 telophase
Tagcloud (Intersection) ?