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NEK2 and TCF25
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
NEK2
TCF25
Gene Name
NIMA-related kinase 2
transcription factor 25 (basic helix-loop-helix)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Kinetochore
Condensed Chromosome Kinetochore
Condensed Nuclear Chromosome
Spindle Pole
Nucleus
Nucleolus
Cytoplasm
Centrosome
Cytosol
Microtubule
Midbody
Protein Complex
Intercellular Bridge
Nucleus
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Phosphatase Binding
Metal Ion Binding
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Biological Process
Mitotic Sister Chromatid Segregation
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Blastocyst Development
Protein Phosphorylation
Organelle Organization
Chromosome Segregation
Mitotic Nuclear Division
Regulation Of Mitotic Nuclear Division
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA Binding
Regulation Of Mitotic Centrosome Separation
Protein Autophosphorylation
Spindle Assembly
Centrosome Separation
Cell Division
Meiotic Cell Cycle
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Mitotic Spindle Assembly
Negative Regulation Of Centriole-centriole Cohesion
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
Heart Development
Pathways
Organelle biogenesis and maintenance
APC/C:Cdc20 mediated degradation of mitotic proteins
Assembly of the primary cilium
G2/M Transition
Anchoring of the basal body to the plasma membrane
Regulation of PLK1 Activity at G2/M Transition
APC/C-mediated degradation of cell cycle proteins
Cell Cycle, Mitotic
Loss of proteins required for interphase microtubule organization from the centrosome
Loss of Nlp from mitotic centrosomes
Regulation of mitotic cell cycle
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Centrosome maturation
Mitotic G2-G2/M phases
Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS
Protein-Protein Interactions
23 interactors:
CCDC85A
CEP250
CHGA
CSN2
CTNNB1
DCTN1
EDRF1
EIF4A2
GIT1
IFT140
IMMT
MAD1L1
MAPK1
MCC
NDC80
NEK11
PDE4DIP
PPP1CA
PPP1CC
PPP1R2
SPTBN4
TCF25
TPM3
8 interactors:
APPBP2
CCDC155
DERL1
GPRASP2
MAGEA11
NEK2
RPS10
SAT1
Entrez ID
4751
22980
HPRD ID
04953
13830
Ensembl ID
ENSG00000117650
ENSG00000141002
Uniprot IDs
P51955
Q9BQ70
PDB IDs
2JAV
2W5A
2W5B
2W5H
2WQO
2XK3
2XK4
2XK6
2XK7
2XK8
2XKC
2XKD
2XKE
2XKF
2XNM
2XNN
2XNO
2XNP
4A4X
4AFE
Enriched GO Terms of Interacting Partners
?
Cell Cycle
Regulation Of Centriole-centriole Cohesion
Glycogen Metabolic Process
Mitotic Cell Cycle
Polysaccharide Metabolic Process
Regulation Of Organelle Organization
Triglyceride Catabolic Process
Entrainment Of Circadian Clock By Photoperiod
Movement Of Cell Or Subcellular Component
Cell Cycle Process
Photoperiodism
Entrainment Of Circadian Clock
Acylglycerol Catabolic Process
Energy Reserve Metabolic Process
Mitotic Cell Cycle Process
Microtubule-based Process
Cell Division
Regulation Of Cellular Response To Growth Factor Stimulus
Negative Regulation Of Mitotic Cell Cycle
Negative Regulation Of RNA-directed RNA Polymerase Activity
Regulation Of Metaphase Plate Congression
Regulation Of Cytoskeleton Organization
Cellular Protein Localization
Cellular Carbohydrate Metabolic Process
Centrosome Cycle
Cellular Response To Growth Factor Stimulus
MAPK Import Into Nucleus
Negative Regulation Of Mitotic Cell Cycle, Embryonic
Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Schwann Cell Proliferation
Cellular Response To Insulin-like Growth Factor Stimulus
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Response To Growth Factor
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Chromosome Segregation
Regulation Of Signal Transduction
Cell Morphogenesis
Circadian Regulation Of Gene Expression
Energy Derivation By Oxidation Of Organic Compounds
Response To Abiotic Stimulus
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation
Renal Inner Medulla Development
Renal Outer Medulla Development
Mesenchymal Cell Proliferation Involved In Lung Development
Glial Cell Fate Determination
Oviduct Development
Mitotic Nuclear Division
Neuron Differentiation
Establishment Of Organelle Localization
Chromosome Localization To Nuclear Envelope Involved In Synapsis
Negative Regulation Of Centriole-centriole Cohesion
Catabolic Process
Spermidine Acetylation
Establishment Of Localization In Cell
Regulation Of Centriole-centriole Cohesion
Putrescine Catabolic Process
Cellular Macromolecule Catabolic Process
Viral Life Cycle
Intracellular Protein Transport
Meiotic Cell Cycle
Regulation Of Mitotic Centrosome Separation
Oxalate Transport
Intracellular Transport Of Viral Protein In Host Cell
Retrograde Protein Transport, ER To Cytosol
Chromosome Segregation
Cellular Localization
Polyamine Catabolic Process
3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Neurotransmitter Uptake
Cellular Protein Localization
Protein Transport
Centrosome Separation
3'-phosphoadenosine 5'-phosphosulfate Metabolic Process
Establishment Of Protein Localization
Polyamine Biosynthetic Process
Intracellular Transport
Mitotic Spindle Assembly
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Amine Biosynthetic Process
Ubiquitin-dependent Protein Catabolic Process
Protein Destabilization
Modification-dependent Protein Catabolic Process
Intracellular Transport Of Virus
Viral Process
Proteolysis Involved In Cellular Protein Catabolic Process
Polyamine Metabolic Process
Cellular Protein Catabolic Process
Protein Localization
Protein Catabolic Process
Sulfate Transmembrane Transport
ER-associated Ubiquitin-dependent Protein Catabolic Process
Establishment Of Chromosome Localization
Sulfate Transport
Mitotic Spindle Organization
Negative Regulation Of DNA Binding
Regulation Of Centrosome Cycle
Neutral Amino Acid Transport
Tagcloud
?
called
complementary
cyclins
dissociated
dnas
ectopic
elucidate
eventually
g2
gst
hec
heptad
hydrolyzes
inhibits
interacts
leucine
mitosis
mitotic
modulate
mss1
p45
proteasome
proteolysis
pull
repeats
seventh
smc1
smc2
telophase
Tagcloud (Difference)
?
called
complementary
cyclins
dissociated
dnas
ectopic
elucidate
eventually
g2
gst
hec
heptad
hydrolyzes
inhibits
interacts
leucine
mitosis
mitotic
modulate
mss1
p45
proteasome
proteolysis
pull
repeats
seventh
smc1
smc2
telophase
Tagcloud (Intersection)
?