GIT1 and TRIB3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GIT1	TRIB3
Gene Name		G protein-coupled receptor kinase interacting ArfGAP 1	tribbles pseudokinase 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Membrane Aggresome	Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding ARF GTPase Activator Activity Zinc Ion Binding	Transcription Corepressor Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity
	Biological Process	Axon Guidance Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of ARF GTPase Activity Regulation Of Cytokinesis Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway	Transcription, DNA-templated Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Glucose Transport Positive Regulation Of Protein Binding Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Fc-epsilon Receptor Signaling Pathway Regulation Of MAP Kinase Activity Cellular Lipid Metabolic Process Small Molecule Metabolic Process Innate Immune Response Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Ubiquitin-protein Transferase Activity Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Pathways		Ephrin signaling Axon guidance EPH-Ephrin signaling	Signaling by the B Cell Receptor (BCR) Metabolism of lipids and lipoproteins Signaling by FGFR in disease Activation of PKB Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Signaling by VEGF Downstream signal transduction Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Adaptive Immune System PPARA activates gene expression Costimulation by the CD28 family Activation of PKB PIP3 activates AKT signaling IRS-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling VEGFR2 mediated vascular permeability Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Fatty acid, triacylglycerol, and ketone body metabolism Insulin receptor signalling cascade Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events NGF signalling via TRKA from the plasma membrane Negative regulation of the PI3K/AKT network Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) PI3K Cascade
Drugs
Diseases
GWAS			Information processing speed ( 21130836)
Protein-Protein Interactions		50 interactors: ADRBK1 ADRBK2 ARHGEF6 ARHGEF7 BARD1 C8orf33 CCDC113 CENPU CHD3 DDX24 EIF6 GIT2 GRB2 GRK5 GRK6 HAP1 HMOX2 HTT KIAA1377 KIF1A LAMTOR5 LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SDCCAG3 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG	21 interactors: AKT1 AKT2 APP ATF4 BMPR2 COPS6 DDIT3 EEF1G GDF9 GIT1 HLA-B HRSP12 KAT5 PRMT5 PSMA3 RBM4 RBM48 RELA RPGRIP1 RPSA SETDB1
Entrez ID		28964	57761
HPRD ID		06577	09836
Ensembl ID		ENSG00000108262	ENSG00000101255
Uniprot IDs		Q59FC3 Q9Y2X7	J3KR25 Q96RU7
PDB IDs
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Growth Factor Regulation Of Signal Transduction Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organonitrogen Compound Cell Cycle Vascular Endothelial Growth Factor Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Termination Of Signal Transduction Glutamate Secretion Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Signal Complex Assembly Regulation Of Neurotransmitter Levels Cellular Response To Organic Substance Immune Response-regulating Cell Surface Receptor Signaling Pathway Dicarboxylic Acid Transport Fibroblast Growth Factor Receptor Signaling Pathway Neurotransmitter Transport Fc Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Protein Kinase Activity Cell Projection Organization Regulation Of Catalytic Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotransmitter Secretion Regulation Of Kinase Activity Response To Peptide Hormone Immune Response-regulating Signaling Pathway Positive Regulation Of Metabolic Process Cell-substrate Adhesion Regulation Of Apoptotic Process Response To Organonitrogen Compound Regulation Of Phosphorus Metabolic Process Response To Peptide Positive Regulation Of Signal Transduction Signaling Acid Secretion Negative Regulation Of Signal Transduction Regulation Of Phosphorylation	Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Gene Expression Cellular Protein Metabolic Process Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Protein Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Regulation Of Translation Viral Process Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Regulation Of Cell Cycle Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Cellular Response To Stress Positive Regulation Of Protein Phosphorylation Regulation Of Gene Expression Response To Nutrient Levels Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Radiation Posttranscriptional Regulation Of Gene Expression Response To Extracellular Stimulus Signal Transduction Peripheral Nervous System Myelin Maintenance Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Glycogen Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Regulation Of Cytokine Production Regulation Of Lipid Transport Negative Regulation Of Biosynthetic Process Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Ion Transport Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Signaling RNA Metabolic Process Regulation Of Fatty Acid Beta-oxidation Apoptotic Process
Tagcloud ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git2 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined	6weeks amounts atf attenuation caspase3 chop db diabetic ebp endoplasmic glp homolog homologous immunoblot inhibiting islets nuclei orally promoted promotes reticulum staining tribbles triggers tunel untreated vildagliptin vs x10
Tagcloud (Difference) ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git2 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined	6weeks amounts atf attenuation caspase3 chop db diabetic ebp endoplasmic glp homolog homologous immunoblot inhibiting islets nuclei orally promoted promotes reticulum staining tribbles triggers tunel untreated vildagliptin vs x10
Tagcloud (Intersection) ?