GIT1 and SDCCAG3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GIT1	SDCCAG3
Gene Name		G protein-coupled receptor kinase interacting ArfGAP 1	serologically defined colon cancer antigen 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Membrane Aggresome	Endosome Early Endosome Midbody Retromer Complex Recycling Endosome
	Molecular Function	Protein Binding ARF GTPase Activator Activity Zinc Ion Binding	Protein Binding
	Biological Process	Axon Guidance Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of ARF GTPase Activity Regulation Of Cytokinesis Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway	Regulation Of Cytokinesis Retrograde Transport, Endosome To Plasma Membrane
Pathways		Ephrin signaling Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		50 interactors: ADRBK1 ADRBK2 ARHGEF6 ARHGEF7 BARD1 C8orf33 CCDC113 CENPU CHD3 DDX24 EIF6 GIT2 GRB2 GRK5 GRK6 HAP1 HMOX2 HTT KIAA1377 KIF1A LAMTOR5 LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SDCCAG3 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG	10 interactors: AP1M1 APP CD99 CHD3 CSNK1E DDX6 GIT1 SDCBP TFPT VIM
Entrez ID		28964	10807
HPRD ID		06577	15307
Ensembl ID		ENSG00000108262	ENSG00000165689
Uniprot IDs		Q59FC3 Q9Y2X7	Q96C92
PDB IDs
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Growth Factor Regulation Of Signal Transduction Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organonitrogen Compound Cell Cycle Vascular Endothelial Growth Factor Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Termination Of Signal Transduction Glutamate Secretion Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Signal Complex Assembly Regulation Of Neurotransmitter Levels Cellular Response To Organic Substance Immune Response-regulating Cell Surface Receptor Signaling Pathway Dicarboxylic Acid Transport Fibroblast Growth Factor Receptor Signaling Pathway Neurotransmitter Transport Fc Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Protein Kinase Activity Cell Projection Organization Regulation Of Catalytic Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotransmitter Secretion Regulation Of Kinase Activity Response To Peptide Hormone Immune Response-regulating Signaling Pathway Positive Regulation Of Metabolic Process Cell-substrate Adhesion Regulation Of Apoptotic Process Response To Organonitrogen Compound Regulation Of Phosphorus Metabolic Process Response To Peptide Positive Regulation Of Signal Transduction Signaling Acid Secretion Negative Regulation Of Signal Transduction Regulation Of Phosphorylation	Axon Guidance Organelle Organization Ephrin Receptor Signaling Pathway Synaptic Growth At Neuromuscular Junction Axonogenesis Collateral Sprouting In Absence Of Injury Axon Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Extracellular Vesicular Exosome Assembly Chemotaxis Collateral Sprouting Axon Midline Choice Point Recognition Neuron Projection Morphogenesis Movement Of Cell Or Subcellular Component Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Extracellular Vesicular Exosome Assembly Axon Choice Point Recognition Generation Of Neurons Cell Morphogenesis Involved In Differentiation Negative Regulation Of Neuron Differentiation Bergmann Glial Cell Differentiation Neurogenesis Pigment Granule Maturation Endosome To Melanosome Transport Neuron Remodeling Neuron Projection Development Cytoplasmic MRNA Processing Body Assembly Cellular Pigment Accumulation Cell Projection Morphogenesis Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Cell Part Morphogenesis Cell Development Response To External Stimulus Substrate-dependent Cell Migration, Cell Extension
Tagcloud ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git2 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined
Tagcloud (Difference) ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git2 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined
Tagcloud (Intersection) ?