GIT1 and RIF1

Number of citations of the paper that reports this interaction (PMID 15383276)
99

Data Source:
HPRD (two hybrid)

		GIT1	RIF1
Gene Name		G protein-coupled receptor kinase interacting ArfGAP 1	replication timing regulatory factor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Membrane Aggresome	Chromosome, Telomeric Region Female Pronucleus Male Pronucleus Nucleus Cytoplasm Spindle Plasma Membrane
	Molecular Function	Protein Binding ARF GTPase Activator Activity Zinc Ion Binding
	Biological Process	Axon Guidance Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of ARF GTPase Activity Regulation Of Cytokinesis Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway	Cellular Response To DNA Damage Stimulus Cell Cycle Stem Cell Maintenance
Pathways		Ephrin signaling Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS			Lung cancer ( 23143601)
Protein-Protein Interactions		50 interactors: ADRBK1 ADRBK2 ARHGEF6 ARHGEF7 BARD1 C8orf33 CCDC113 CENPU CHD3 DDX24 EIF6 GIT2 GRB2 GRK5 GRK6 HAP1 HMOX2 HTT KIAA1377 KIF1A LAMTOR5 LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SDCCAG3 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG	18 interactors: BRD7 CHD3 DEFB1 FEZ1 GIT1 GNE GRB2 HAP1 HMP19 KIAA1377 PABPC4 PIAS4 POT1 PPP1CA PPP1CC SETDB1 SMARCD1 TERF2IP
Entrez ID		28964	55183
HPRD ID		06577	10603
Ensembl ID		ENSG00000108262	ENSG00000080345
Uniprot IDs		Q59FC3 Q9Y2X7	Q5UIP0
PDB IDs
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Growth Factor Regulation Of Signal Transduction Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organonitrogen Compound Cell Cycle Vascular Endothelial Growth Factor Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Termination Of Signal Transduction Glutamate Secretion Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Signal Complex Assembly Regulation Of Neurotransmitter Levels Cellular Response To Organic Substance Immune Response-regulating Cell Surface Receptor Signaling Pathway Dicarboxylic Acid Transport Fibroblast Growth Factor Receptor Signaling Pathway Neurotransmitter Transport Fc Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Protein Kinase Activity Cell Projection Organization Regulation Of Catalytic Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotransmitter Secretion Regulation Of Kinase Activity Response To Peptide Hormone Immune Response-regulating Signaling Pathway Positive Regulation Of Metabolic Process Cell-substrate Adhesion Regulation Of Apoptotic Process Response To Organonitrogen Compound Regulation Of Phosphorus Metabolic Process Response To Peptide Positive Regulation Of Signal Transduction Signaling Acid Secretion Negative Regulation Of Signal Transduction Regulation Of Phosphorylation	Telomere Maintenance Via Telomere Lengthening Telomere Capping Telomere Maintenance Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Cell Cycle Cellular Response To Growth Factor Stimulus Response To Growth Factor Chromosome Organization Cellular Macromolecule Biosynthetic Process Regulation Of Telomere Maintenance Macromolecule Biosynthetic Process Triglyceride Catabolic Process Regulation Of Response To DNA Damage Stimulus RNA-dependent DNA Replication Entrainment Of Circadian Clock By Photoperiod Cell Surface Receptor Signaling Pathway Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Positive Regulation Of Organelle Organization Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Regulation Of Organelle Organization Regulation Of Chromosome Organization Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Carbohydrate Metabolic Process Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Recombination At Telomere Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated Chemotaxis Biosynthetic Process Glycogen Metabolic Process Regulation Of Gene Expression Regulation Of DNA Repair Organelle Organization DNA Replication RNA Biosynthetic Process Positive Regulation Of Response To DNA Damage Stimulus RNA Metabolic Process Cell Projection Organization Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Response To External Stimulus
Tagcloud ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git2 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined	53bp1 artemis brca1 collectively competes decided deficient doubly downstream effector effectors enzymatic homolog homologous interacting joining nonhomologous nuclease parp parpi parpis prevents ptip rap1 recombination repair resection restores uncovered
Tagcloud (Difference) ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git2 gtpase guanine hippo hpo mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined	53bp1 artemis brca1 collectively competes decided deficient doubly downstream effector effectors enzymatic homolog homologous joining nonhomologous nuclease parp parpi parpis prevents ptip rap1 recombination repair resection restores uncovered
Tagcloud (Intersection) ?		interacting