GIT1 and GRK5

Number of citations of the paper that reports this interaction (PMID 9826657)
60

Data Source:
HPRD (in vivo)

		GIT1	GRK5
Gene Name		G protein-coupled receptor kinase interacting ArfGAP 1	G protein-coupled receptor kinase 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Membrane Aggresome	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Focal Adhesion Nuclear Membrane
	Molecular Function	Protein Binding ARF GTPase Activator Activity Zinc Ion Binding	Protein Serine/threonine Kinase Activity G-protein Coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding
	Biological Process	Axon Guidance Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of ARF GTPase Activity Regulation Of Cytokinesis Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway	Apoptotic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Wnt Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Protein Autophosphorylation
Pathways		Ephrin signaling Axon guidance EPH-Ephrin signaling	G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Type 2 diabetes ( 22961080)
Protein-Protein Interactions		50 interactors: ADRBK1 ADRBK2 ARHGEF6 ARHGEF7 BARD1 C8orf33 CCDC113 CENPU CHD3 DDX24 EIF6 GIT2 GRB2 GRK5 GRK6 HAP1 HMOX2 HTT KIAA1377 KIF1A LAMTOR5 LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SDCCAG3 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG	19 interactors: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R
Entrez ID		28964	2869
HPRD ID		06577	02926
Ensembl ID		ENSG00000108262	ENSG00000198873
Uniprot IDs		Q59FC3 Q9Y2X7	P34947
PDB IDs
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Growth Factor Regulation Of Signal Transduction Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organonitrogen Compound Cell Cycle Vascular Endothelial Growth Factor Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Termination Of Signal Transduction Glutamate Secretion Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Signal Complex Assembly Regulation Of Neurotransmitter Levels Cellular Response To Organic Substance Immune Response-regulating Cell Surface Receptor Signaling Pathway Dicarboxylic Acid Transport Fibroblast Growth Factor Receptor Signaling Pathway Neurotransmitter Transport Fc Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Protein Kinase Activity Cell Projection Organization Regulation Of Catalytic Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotransmitter Secretion Regulation Of Kinase Activity Response To Peptide Hormone Immune Response-regulating Signaling Pathway Positive Regulation Of Metabolic Process Cell-substrate Adhesion Regulation Of Apoptotic Process Response To Organonitrogen Compound Regulation Of Phosphorus Metabolic Process Response To Peptide Positive Regulation Of Signal Transduction Signaling Acid Secretion Negative Regulation Of Signal Transduction Regulation Of Phosphorylation	Regulation Of Vasoconstriction Positive Regulation Of Vasoconstriction Cytosolic Calcium Ion Homeostasis Blood Circulation G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Blood Pressure Signaling Regulation Of Systemic Arterial Blood Pressure Cell Communication Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Response To External Stimulus Metal Ion Homeostasis Regulation Of Catalytic Activity Regulation Of Renal Sodium Excretion Cell Surface Receptor Signaling Pathway Regulation Of Excretion Positive Regulation Of Catalytic Activity Cellular Chemical Homeostasis Regulation Of Systemic Arterial Blood Pressure By Vasopressin Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Ion Homeostasis Regulation Of Phospholipase Activity Chemical Homeostasis Regulation Of Ion Transport Homeostatic Process Positive Regulation Of Blood Pressure Cellular Homeostasis Positive Regulation Of Lyase Activity Response To Abiotic Stimulus Regulation Of Smooth Muscle Contraction Aggressive Behavior Regulation Of Muscle Contraction Regulation Of Cyclase Activity Synaptic Transmission Regulation Of Blood Vessel Size Regulation Of Calcium Ion Transport Regulation Of Tube Size Regulation Of Oxidoreductase Activity Positive Regulation Of Phospholipase Activity Cellular Response To Stimulus Positive Regulation Of Cyclic Nucleotide Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Lipase Activity Negative Regulation Of Ion Transport
Tagcloud ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git2 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined	adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip
Tagcloud (Difference) ?		ancient autophosphorylation coordinates deregulated dimerization exchange gef git2 gtpase guanine hippo hpo interacting mammals melanogaster metazoan oligomeric originally pak pix polarity proteomics rho rtgef salvador scaffold sterile undefined	adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip
Tagcloud (Intersection) ?