GFER and COPS5

Number of citations of the paper that reports this interaction (PMID 11709497)
18

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		GFER	COPS5
Gene Name		growth factor, augmenter of liver regeneration	COP9 signalosome subunit 5
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Intermembrane Space	Nucleus Nucleoplasm Cytoplasm Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Growth Factor Activity Protein Disulfide Oxidoreductase Activity Thiol Oxidase Activity Flavin Adenine Dinucleotide Binding	Transcription Coactivator Activity Translation Initiation Factor Activity Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Metal Ion Binding
	Biological Process	Protein Targeting To Mitochondrion Cellular Protein Metabolic Process Oxidation-reduction Process	Protein Deneddylation Transcription From RNA Polymerase II Promoter Translation Translational Initiation Proteolysis Cullin Deneddylation Protein Deubiquitination Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of JNK Cascade Regulation Of Cell Cycle Exosomal Secretion
Pathways		Mitochondrial protein import
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ASCC2 BNIPL COPS2 COPS5 PLEKHF2 SMAD2 TXN	90 interactors: APCS ARFGAP1 ATRN BCL2L14 BCL3 C12orf10 C6orf203 CACNA1C CD93 CDKN1B CENPT CHUK COPS2 COPS3 COPS4 COPS6 COPS7A COPS8 CUL1 CUL2 CUL4A CUL5 DDB1 DDO ERN1 ESR1 F2RL1 GFER GFI1B GPS1 HAND2 HIF1A HNF4A HNF4G HTR6 HUS1 ITGB2 JUN JUND LOC284014 MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 NR5A2 OPRM1 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 TOP2A TP53 TXN TYK2 UCHL1 USP14 VTN WNK1 YWHAG
Entrez ID		2671	10987
HPRD ID		02954	06888
Ensembl ID		ENSG00000127554	ENSG00000121022
Uniprot IDs		P55789	Q92905
PDB IDs		3MBG 3O55 3TK0 3U2L 3U2M 3U5S	4F7O
Enriched GO Terms of Interacting Partners?		Cullin Deneddylation Protein Deneddylation Transcription, DNA-templated RNA Biosynthetic Process Protein Modification By Small Protein Removal Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry RNA Metabolic Process Regulation Of Growth Rate Zygotic Specification Of Dorsal/ventral Axis Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Exosomal Secretion Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Mesoderm Development Primary MiRNA Processing Negative Regulation Of Protein Export From Nucleus Regulation Of Nodal Signaling Pathway Common-partner SMAD Protein Phosphorylation Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Binding Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death SMAD Protein Complex Assembly Nucleobase-containing Compound Metabolic Process Regulation Of Hydrogen Peroxide-induced Cell Death Paraxial Mesoderm Morphogenesis Nodal Signaling Pathway Nucleobase-containing Small Molecule Interconversion Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Production Of MiRNAs Involved In Gene Silencing By MiRNA Embryonic Foregut Morphogenesis Foregut Morphogenesis	Positive Regulation Of Cellular Metabolic Process Response To Stress Cellular Response To Stimulus Response To Stimulus Cellular Response To Stress Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Organic Substance Cell Communication Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Gene Expression Signaling Cullin Deneddylation Positive Regulation Of Cellular Biosynthetic Process Death Anatomical Structure Development Cellular Response To Organic Substance Response To Abiotic Stimulus Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Cellular Process Response To Lipid Developmental Process Cell Death Multicellular Organismal Development Protein Deneddylation Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Response To Organic Cyclic Compound Apoptotic Process Programmed Cell Death System Development Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Cell Death Response To Radiation Organ Development Defense Response Cell Proliferation Regulation Of Phosphorus Metabolic Process
Tagcloud ?		acting alr apoptotic augmenter behaviour caspase clusterin complementary encodes erv1 glioma hepatectomized integrity lethal modulates named neuroblastoma normoxic oxidase peroxide preserve ralr regenerating regeneration ros shed sulfhydryl supports t98g	abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite
Tagcloud (Difference) ?		acting alr apoptotic augmenter behaviour caspase clusterin complementary encodes erv1 glioma hepatectomized integrity lethal modulates named neuroblastoma normoxic oxidase peroxide preserve ralr regenerating regeneration ros shed sulfhydryl supports t98g	abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite
Tagcloud (Intersection) ?