COPS5 and S100A7

Number of citations of the paper that reports this interaction (PMID 12702588)
22

Data Source:
HPRD (two hybrid, in vivo)

		COPS5	S100A7
Gene Name		COP9 signalosome subunit 5	S100 calcium binding protein A7
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Cell Junction Perinuclear Region Of Cytoplasm	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Focal Adhesion Extracellular Vesicular Exosome
	Molecular Function	Transcription Coactivator Activity Translation Initiation Factor Activity Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Metal Ion Binding	Calcium Ion Binding Protein Binding Zinc Ion Binding RAGE Receptor Binding
	Biological Process	Protein Deneddylation Transcription From RNA Polymerase II Promoter Translation Translational Initiation Proteolysis Cullin Deneddylation Protein Deubiquitination Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of JNK Cascade Regulation Of Cell Cycle Exosomal Secretion	Response To Reactive Oxygen Species Angiogenesis Epidermis Development Positive Regulation Of T Cell Chemotaxis Keratinocyte Differentiation Response To Lipopolysaccharide Innate Immune Response Defense Response To Gram-negative Bacterium Sequestering Of Metal Ion Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Granulocyte Chemotaxis Positive Regulation Of Monocyte Chemotaxis
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		90 interactors: APCS ARFGAP1 ATRN BCL2L14 BCL3 C12orf10 C6orf203 CACNA1C CD93 CDKN1B CENPT CHUK COPS2 COPS3 COPS4 COPS6 COPS7A COPS8 CUL1 CUL2 CUL4A CUL5 DDB1 DDO ERN1 ESR1 F2RL1 GFER GFI1B GPS1 HAND2 HIF1A HNF4A HNF4G HTR6 HUS1 ITGB2 JUN JUND LOC284014 MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 NR5A2 OPRM1 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 TOP2A TP53 TXN TYK2 UCHL1 USP14 VTN WNK1 YWHAG	6 interactors: COPS5 EGFR FABP5 RANBP9 TGM2 UCHL5
Entrez ID		10987	6278
HPRD ID		06888	02645
Ensembl ID		ENSG00000121022	ENSG00000143556
Uniprot IDs		Q92905	P31151
PDB IDs		4F7O	1PSR 2PSR 2WND 2WOR 2WOS 3PSR 4AQJ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Response To Stress Cellular Response To Stimulus Response To Stimulus Cellular Response To Stress Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Organic Substance Cell Communication Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Gene Expression Signaling Cullin Deneddylation Positive Regulation Of Cellular Biosynthetic Process Death Anatomical Structure Development Cellular Response To Organic Substance Response To Abiotic Stimulus Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Cellular Process Response To Lipid Developmental Process Cell Death Multicellular Organismal Development Protein Deneddylation Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Response To Organic Cyclic Compound Apoptotic Process Programmed Cell Death System Development Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Cell Death Response To Radiation Organ Development Defense Response Cell Proliferation Regulation Of Phosphorus Metabolic Process	Salivary Gland Morphogenesis Salivary Gland Development Positive Regulation Of Smooth Muscle Cell Proliferation Exocrine System Development Positive Regulation Of Inflammatory Response Alkanesulfonate Metabolic Process Regulation Of Smooth Muscle Cell Proliferation Protein Deubiquitination Protein Modification By Small Protein Removal Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Astrocyte Activation Gland Morphogenesis Activation Of Phospholipase A2 Activity Exosomal Secretion Positive Regulation Of Phospholipase A2 Activity Organ Morphogenesis Anatomical Structure Morphogenesis Response To Cobalamin Response To UV-A Salivary Gland Cavitation Response To Hydroxyisoflavone Epithelium Development Epidermis Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation Anatomical Structure Development Regulation Of Inflammatory Response Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Cullin Deneddylation Telencephalon Development Regulation Of Signal Transduction Positive Regulation Of Catenin Import Into Nucleus Protein Deneddylation Regulation Of Phospholipase A2 Activity Regulation Of Superoxide Anion Generation Developmental Process Regulation Of Signaling Magnesium Ion Homeostasis Regulation Of Protein Catabolic Process Axon Guidance Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Mitochondrial Calcium Ion Homeostasis Cellular Protein Modification Process Tube Morphogenesis Cellular Response To Estradiol Stimulus Forebrain Development Protein Insertion Into Membrane Astrocyte Development
Tagcloud ?		abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite	29b cdc42 conclusionsthe dataset decoy determining downregulates elaborated elusive inverted mark markb mcf7 methodswe mir modulations nude p85 psoriasin question represented resultsin reversing suppressing tcga transfecting upregulates verified
Tagcloud (Difference) ?		abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite	29b cdc42 conclusionsthe dataset decoy determining downregulates elaborated elusive inverted mark markb mcf7 methodswe mir modulations nude p85 psoriasin question represented resultsin reversing suppressing tcga transfecting upregulates verified
Tagcloud (Intersection) ?