COPS5 and ITGB2

Number of citations of the paper that reports this interaction (PMID 10766246)
39

Data Source:
BioGRID (pull down, two hybrid)

		COPS5	ITGB2
Gene Name		COP9 signalosome subunit 5	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Cell Junction Perinuclear Region Of Cytoplasm	Plasma Membrane Integrin Complex Cell Surface Membrane Vesicle Integrin AlphaL-beta2 Complex Receptor Complex Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Transcription Coactivator Activity Translation Initiation Factor Activity Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Metal Ion Binding	Glycoprotein Binding Protein Binding Protein Kinase Binding ICAM-3 Receptor Activity Protein Complex Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Protein Deneddylation Transcription From RNA Polymerase II Promoter Translation Translational Initiation Proteolysis Cullin Deneddylation Protein Deubiquitination Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of JNK Cascade Regulation Of Cell Cycle Exosomal Secretion	Toll-like Receptor Signaling Pathway Leukocyte Migration Involved In Inflammatory Response Apoptotic Process Inflammatory Response Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Signaling Aging Blood Coagulation Regulation Of Cell Shape Natural Killer Cell Activation Extracellular Matrix Organization Neutrophil Chemotaxis Heterotypic Cell-cell Adhesion Toll-like Receptor 4 Signaling Pathway Endodermal Cell Differentiation Receptor Clustering Endothelial Cell Migration Innate Immune Response Cellular Extravasation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Activated T Cell Proliferation Leukocyte Migration Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways			Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Adaptive Immune System Innate Immune System
Drugs			Simvastatin
Diseases
GWAS
Protein-Protein Interactions		90 interactors: APCS ARFGAP1 ATRN BCL2L14 BCL3 C12orf10 C6orf203 CACNA1C CD93 CDKN1B CENPT CHUK COPS2 COPS3 COPS4 COPS6 COPS7A COPS8 CUL1 CUL2 CUL4A CUL5 DDB1 DDO ERN1 ESR1 F2RL1 GFER GFI1B GPS1 HAND2 HIF1A HNF4A HNF4G HTR6 HUS1 ITGB2 JUN JUND LOC284014 MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 NR5A2 OPRM1 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 TOP2A TP53 TXN TYK2 UCHL1 USP14 VTN WNK1 YWHAG	41 interactors: CD14 CD226 CD82 COPS3 COPS5 CYTH1 CYTH2 DAB1 DOK1 ESM1 FCER2 FHL2 FUT4 GNB2L1 HP ICAM1 ICAM2 ICAM3 ICAM4 ICAM5 ILK ITGAD ITGAM ITGAX KNG1 NOTCH2NL NUMB PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRTN3 PTK2 PTK2B RANBP9 RDX SYK TLN1 VNN2
Entrez ID		10987	3689
HPRD ID		06888	02506
Ensembl ID		ENSG00000121022	ENSG00000160255
Uniprot IDs		Q92905	A8MYE6 P05107
PDB IDs		4F7O	1JX3 1L3Y 1YUK 2JF1 2P26 2P28 2V7D 3K6S 3K71 3K72
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Response To Stress Cellular Response To Stimulus Response To Stimulus Cellular Response To Stress Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Organic Substance Cell Communication Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Gene Expression Signaling Cullin Deneddylation Positive Regulation Of Cellular Biosynthetic Process Death Anatomical Structure Development Cellular Response To Organic Substance Response To Abiotic Stimulus Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Cellular Process Response To Lipid Developmental Process Cell Death Multicellular Organismal Development Protein Deneddylation Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Response To Organic Cyclic Compound Apoptotic Process Programmed Cell Death System Development Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Cell Death Response To Radiation Organ Development Defense Response Cell Proliferation Regulation Of Phosphorus Metabolic Process	Blood Coagulation Hemostasis Platelet Activation Cell Activation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Cell Adhesion Regulation Of Immune System Process Regulation Of Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Single Organismal Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Immune System Process Integrin-mediated Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Signal Transduction Defense Response Signal Transduction Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Glial Cell Apoptotic Process Movement Of Cell Or Subcellular Component Locomotion Regulation Of Signaling Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To External Stimulus Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Immune Response Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Immune System Process Positive Regulation Of Phosphorylation Leukocyte Activation Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Activation Of Phospholipase C Activity
Tagcloud ?		abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite	a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgal loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly
Tagcloud (Difference) ?		abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite	a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgal loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly
Tagcloud (Intersection) ?