GBP2 and MAPK8IP2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		GBP2	MAPK8IP2
Gene Name		guanylate binding protein 2, interferon-inducible	mitogen-activated protein kinase 8 interacting protein 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Cytosol Symbiont-containing Vacuole Membrane Cytoplasmic Vesicle	Cytoplasm Neuronal Cell Body Protein Complex Neuronal Postsynaptic Density
	Molecular Function	GTPase Activity Protein Binding GTP Binding	Beta-amyloid Binding MAP-kinase Scaffold Activity Structural Molecule Activity Protein Binding Kinesin Binding Protein Kinase Binding Protein Kinase Activator Activity Protein Complex Binding
	Biological Process	Immune Response Metabolic Process Cytokine-mediated Signaling Pathway Cellular Response To Interferon-beta Defense Response To Protozoan Adhesion Of Symbiont To Host Defense Response To Gram-positive Bacterium Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Lipopolysaccharide	MAPK Cascade Behavioral Fear Response Signal Complex Assembly JNK Cascade Mating Behavior Regulation Of Receptor Activity Positive Regulation Of Stress-activated MAPK Cascade Social Behavior Positive Regulation Of Protein Kinase Activity Regulation Of JNK Cascade Nonassociative Learning Dendrite Morphogenesis Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: ANXA7 BID BNIP3L BTBD2 CSNK2B FXR1 GADD45A GSK3B HSPE1 KLHL20 LSM2 MAGI1 MAPK8IP2 PAFAH1B3 PPP1R8 RPS6KA1 SAT1 SEPHS1 SERPINB9 STK3 TFG	52 interactors: ADRB2 AFG3L2 APP ASRGL1 BBS10 C14orf1 CFL1 CHN1 CRMP1 DUSP16 EGFR ERBB2 EZH2 FGF12 FSCN1 GBP2 ITSN1 KIFC2 KLC1 LRP1 LRP2 LRP8 MAGED4B MAP2K3 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAPK10 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MASP1 NDUFS6 PLXNA3 PRSS23 RAI1 RBX1 RPS6KB2 SMARCB1 SMS SYNE2 TIAM1 TP53BP2 UNC119 VCP VPS33B VRK2 YY1AP1 ZNF593 ZNF784
Entrez ID		2634	23542
HPRD ID		02682	09674
Ensembl ID		ENSG00000162645	ENSG00000008735
Uniprot IDs		P32456 Q8TCE5	Q13387
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Death Death Apoptotic Process Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Positive Regulation Of Cell Death Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Mitochondrial Outer Membrane Permeabilization Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of MAPK Cascade Hepatocyte Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Protein Phosphorylation Apoptotic Signaling Pathway Regulation Of Proteolysis Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Response To Stimulus Positive Regulation Of Protein Phosphorylation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Endopeptidase Activity Regulation Of Protein Kinase Activity Regulation Of Peptidase Activity Regulation Of JNK Cascade Regulation Of Intracellular Signal Transduction Negative Regulation Of Catalytic Activity Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Kinase Activity Regulation Of Mitochondrial Membrane Permeability Catabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Membrane Permeability Regulation Of Stress-activated MAPK Cascade Regulation Of Phosphorylation Social Behavior Positive Regulation Of Phosphorylation Response To Organic Substance	Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade JNK Cascade Signal Transduction By Phosphorylation MAPK Cascade Regulation Of Protein Kinase Activity Regulation Of MAPK Cascade Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity JUN Phosphorylation Regulation Of MAP Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Positive Regulation Of MAP Kinase Activity Response To Stress Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAPK Cascade Regulation Of Signal Transduction Response To Light Stimulus Response To External Stimulus Response To Radiation Regulation Of Signaling Intracellular Signal Transduction Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Axon Guidance Regulation Of Intracellular Signal Transduction Signal Transduction Axonogenesis Phosphorylation Cell Part Morphogenesis Axon Development Response To Stimulus Cell Morphogenesis Involved In Neuron Differentiation Response To Abiotic Stimulus Protein Phosphorylation Cellular Response To Stress Signaling
Tagcloud ?		anthracycline besides carcinomas chemotherapy erbb2 fast grading guanylate hazard inducible infiltration interestingly interferon kappa metalloproteinase node odds pathologically probably prognosis proliferating pt rac reach receive represents signature subgroups univariate
Tagcloud (Difference) ?		anthracycline besides carcinomas chemotherapy erbb2 fast grading guanylate hazard inducible infiltration interestingly interferon kappa metalloproteinase node odds pathologically probably prognosis proliferating pt rac reach receive represents signature subgroups univariate
Tagcloud (Intersection) ?