SASH1 and KHDRBS1

Number of citations of the paper that reports this interaction (PMID 22745667)
1

Data Source:
BioGRID (unspecified method)

		SASH1	KHDRBS1
Gene Name		SAM and SH3 domain containing 1	KH domain containing, RNA binding, signal transduction associated 1
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Gene Ontology Annotations	Cellular Component	Membrane Protein Complex	Nucleus Nucleoplasm Cytoplasm Membrane Grb2-Sos Complex
	Molecular Function	Protein C-terminus Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Complex Scaffold	DNA Binding RNA Binding SH3/SH2 Adaptor Activity Protein Binding Poly(A) Binding Poly(U) RNA Binding SH3 Domain Binding Protein Complex Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Angiogenesis Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of P38MAPK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Protein Autoubiquitination	G2/M Transition Of Mitotic Cell Cycle Transcription, DNA-templated MRNA Processing Cell Cycle Arrest Signal Transduction Cell Surface Receptor Signaling Pathway Cell Proliferation Positive Regulation Of Signal Transduction Regulation Of Protein Stability Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Translational Initiation Regulation Of RNA Export From Nucleus Positive Regulation Of RNA Export From Nucleus
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease ( 20061627) Protein quantitative trait loci ( 18464913) Thyroid hormone levels ( 23408906) Type 2 diabetes nephropathy ( 21150874)
Protein-Protein Interactions		2 interactors: KHDRBS1 SKIL	109 interactors: ABI2 ACTB AGO1 AHI1 AMPH APBB1 ARHGEF4 ARHGEF9 AZIN1 BAIAP2L1 BTK BZRAP1 CBL CD2AP CDK1 CIRBP CREB3L3 CREBBP CRK CRKL CSK DDX5 DHX9 DLG1 DLG2 DLG3 DLG4 DNMBP DOCK2 DOCK3 EFEMP1 EMG1 FGR FNBP4 FRK FYN GAS7 GPHN GRAP GRAP2 GRB2 HCK HNRNPK INSR ITK ITSN1 ITSN2 JAK3 KHDRBS3 LCK LYN MAPK1 MIA2 MPP6 MYO1C MYO7A NCF1 NCK1 NCK2 NCKIPSD NPHP1 OSTF1 PACSIN1 PIK3R1 PIK3R3 PLCG1 PLCG2 POT1 PPP1R13B PRMT1 PSTPIP1 PTBP2 PTK6 PTPN6 RALY RAPSN RASA1 RBFOX2 RBM7 RBMX RUSC2 SASH1 SCG5 SH3PXD2A SH3YL1 SKAP2 SMAD2 SMARCA2 SNX30 SNX9 SORBS1 SPATA13 SRC SSFA2 STAT3 STUB1 TBL1X TJP1 TNFSF11 TUBB3 U2AF2 UBA52 UBASH3B VAV1 WBP4 YES1 YTHDC1 ZBTB7A ZDHHC6
Entrez ID		23328	10657
HPRD ID		06408	03926
Ensembl ID		ENSG00000111961	ENSG00000121774
Uniprot IDs		O94885	Q07666
PDB IDs		2DL0 2EBP	2XA6 3QHE
Enriched GO Terms of Interacting Partners?		Cell Cycle Arrest Positive Regulation Of RNA Export From Nucleus Negative Regulation Of Cell Cycle Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Heterotrimerization Regulation Of RNA Export From Nucleus Positive Regulation Of Translational Initiation Protein Homotrimerization Regulation Of Cell Cycle Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cell Cycle Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Lens Fiber Cell Differentiation Protein Trimerization Positive Regulation Of Signal Transduction Negative Regulation Of Gene Expression Blastocyst Formation Negative Regulation Of Biosynthetic Process Cell Cycle Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Antibiotic Positive Regulation Of Response To DNA Damage Stimulus Lymphocyte Homeostasis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Translational Initiation Positive Regulation Of Translation Positive Regulation Of Axonogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Leukocyte Homeostasis Negative Regulation Of Cellular Metabolic Process Lens Development In Camera-type Eye Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Blastocyst Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Nucleocytoplasmic Transport Transcription, DNA-templated G2/M Transition Of Mitotic Cell Cycle RNA Biosynthetic Process Regulation Of Response To DNA Damage Stimulus Protein Heterooligomerization Skeletal Muscle Tissue Development Transforming Growth Factor Beta Receptor Signaling Pathway Skeletal Muscle Organ Development Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Axonogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Communication Peptidyl-tyrosine Autophosphorylation Innate Immune Response Signal Transduction Immune Response-regulating Signaling Pathway Immune Response Endocytosis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Locomotion Movement Of Cell Or Subcellular Component Cellular Response To Stimulus Positive Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Defense Response Positive Regulation Of Immune Response Regulation Of Immune System Process Cellular Response To Peptide Hormone Stimulus Neurotrophin TRK Receptor Signaling Pathway Phagocytosis Cellular Response To Peptide Positive Regulation Of Immune System Process Neurotrophin Signaling Pathway Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Immune Response Epidermal Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Growth Factor Antigen Receptor-mediated Signaling Pathway Cell Differentiation Regulation Of Catalytic Activity Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Component Organization Immune System Process Response To Stimulus Regulation Of Signaling Cell Projection Organization Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Metabolic Process
Tagcloud ?		adjacent analyse aza cpg degree deoxycytidine elevation follows g2 hep hepatocellular liver massarray methylation particularly pattern pcr possibly promoter propose quantitative real relationship repressed rt shared sites strongly tissues
Tagcloud (Difference) ?		adjacent analyse aza cpg degree deoxycytidine elevation follows g2 hep hepatocellular liver massarray methylation particularly pattern pcr possibly promoter propose quantitative real relationship repressed rt shared sites strongly tissues
Tagcloud (Intersection) ?