EZH2 and MAPK8IP2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		EZH2	MAPK8IP2
Gene Name		enhancer of zeste 2 polycomb repressive complex 2 subunit	mitogen-activated protein kinase 8 interacting protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm ESC/E(Z) Complex Pronucleus	Cytoplasm Neuronal Cell Body Protein Complex Neuronal Postsynaptic Density
	Molecular Function	Core Promoter Binding DNA Binding Chromatin Binding RNA Binding Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Chromatin DNA Binding Histone Methyltransferase Activity Sequence-specific DNA Binding Histone Methyltransferase Activity (H3-K27 Specific)	Beta-amyloid Binding MAP-kinase Scaffold Activity Structural Molecule Activity Protein Binding Kinesin Binding Protein Kinase Binding Protein Kinase Activator Activity Protein Complex Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Gliogenesis Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Cerebellar Cortex Development Positive Regulation Of Ras GTPase Activity Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Regulation Of Circadian Rhythm Positive Regulation Of MAP Kinase Activity Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Rhythmic Process Negative Regulation Of Striated Muscle Cell Differentiation Cellular Response To Hydrogen Peroxide G1 To G0 Transition Histone H3-K27 Methylation Protein Localization To Chromatin Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	MAPK Cascade Behavioral Fear Response Signal Complex Assembly JNK Cascade Mating Behavior Regulation Of Receptor Activity Positive Regulation Of Stress-activated MAPK Cascade Social Behavior Positive Regulation Of Protein Kinase Activity Regulation Of JNK Cascade Nonassociative Learning Dendrite Morphogenesis Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity
Pathways		Oxidative Stress Induced Senescence Cellular Senescence Epigenetic regulation of gene expression PRC2 methylates histones and DNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		64 interactors: AKT1 ATP1A1 ATP1B1 ATRX BRCA1 C7orf25 CCDC85B CDK1 CDK2 CDK6 CDKN2B-AS1 CEP63 DNAJB11 DNMT1 DNMT3A DNMT3B E2F6 EED EHMT1 EPC2 GADD45G GTF3C1 HDAC1 HIST1H1A HIST1H3A HIST3H3 HOTAIR JAK2 KDM1A KLHDC2 MAP3K7 MAPK8IP2 MAPKAPK3 MED1 NINL PFDN1 PHB2 PHF1 PIN4 PJA1 POLA2 PRMT5 PSMB6 RASA1 RBBP4 RBL2 RELA RELB RPN2 RPS6KA5 SMN1 SMS SMYD3 SUV39H1 SUZ12 TAF1D TK1 TNFSF11 USP7 VAV1 WDR61 WSB2 ZAK ZMYND11	52 interactors: ADRB2 AFG3L2 APP ASRGL1 BBS10 C14orf1 CFL1 CHN1 CRMP1 DUSP16 EGFR ERBB2 EZH2 FGF12 FSCN1 GBP2 ITSN1 KIFC2 KLC1 LRP1 LRP2 LRP8 MAGED4B MAP2K3 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAPK10 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MASP1 NDUFS6 PLXNA3 PRSS23 RAI1 RBX1 RPS6KB2 SMARCB1 SMS SYNE2 TIAM1 TP53BP2 UNC119 VCP VPS33B VRK2 YY1AP1 ZNF593 ZNF784
Entrez ID		2146	23542
HPRD ID		03342	09674
Ensembl ID		ENSG00000106462	ENSG00000008735
Uniprot IDs		Q15910 S4S3R8	Q13387
PDB IDs		2C6V 4MI0
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Modification Chromosome Organization Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Organelle Organization Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Modification Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Modification Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Histone Methylation Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Histone Methylation Macromolecule Biosynthetic Process Methylation Cell Cycle Negative Regulation Of Histone Methylation Positive Regulation Of Histone Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Histone Modification Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Histone H3-K4 Methylation Intracellular Signal Transduction	Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade JNK Cascade Signal Transduction By Phosphorylation MAPK Cascade Regulation Of Protein Kinase Activity Regulation Of MAPK Cascade Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity JUN Phosphorylation Regulation Of MAP Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Positive Regulation Of MAP Kinase Activity Response To Stress Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAPK Cascade Regulation Of Signal Transduction Response To Light Stimulus Response To External Stimulus Response To Radiation Regulation Of Signaling Intracellular Signal Transduction Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Axon Guidance Regulation Of Intracellular Signal Transduction Signal Transduction Axonogenesis Phosphorylation Cell Part Morphogenesis Axon Development Response To Stimulus Cell Morphogenesis Involved In Neuron Differentiation Response To Abiotic Stimulus Protein Phosphorylation Cellular Response To Stress Signaling
Tagcloud ?		70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm eed esc fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste
Tagcloud (Difference) ?		70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm eed esc fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste
Tagcloud (Intersection) ?