EZH2 and CDK1

Number of citations of the paper that reports this interaction (PMID 21123648)
80

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study)

		EZH2	CDK1
Gene Name		enhancer of zeste 2 polycomb repressive complex 2 subunit	cyclin-dependent kinase 1
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm ESC/E(Z) Complex Pronucleus	Nucleus Nucleoplasm Cytoplasm Mitochondrion Centrosome Cytosol Spindle Microtubule Membrane Midbody Extracellular Vesicular Exosome Mitotic Spindle
	Molecular Function	Core Promoter Binding DNA Binding Chromatin Binding RNA Binding Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Chromatin DNA Binding Histone Methyltransferase Activity Sequence-specific DNA Binding Histone Methyltransferase Activity (H3-K27 Specific)	Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity Cyclin Binding Hsp70 Protein Binding Histone Kinase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Gliogenesis Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Cerebellar Cortex Development Positive Regulation Of Ras GTPase Activity Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Regulation Of Circadian Rhythm Positive Regulation Of MAP Kinase Activity Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Rhythmic Process Negative Regulation Of Striated Muscle Cell Differentiation Cellular Response To Hydrogen Peroxide G1 To G0 Transition Histone H3-K27 Methylation Protein Localization To Chromatin Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Microtubule Cytoskeleton Organization Mitotic Cell Cycle Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway DNA Replication DNA Repair Protein Complex Assembly Apoptotic Process Organelle Organization Mitotic Nuclear Division Mitotic Nuclear Envelope Disassembly Mitotic G2 DNA Damage Checkpoint Centrosome Cycle Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Pronuclear Fusion Axon Guidance Cell Aging Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Toxic Substance Positive Regulation Of Gene Expression Regulation Of Schwann Cell Differentiation Response To Organic Cyclic Compound Response To Amine Response To Activity Cell Migration Histone Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Chromosome Condensation Epithelial Cell Differentiation Organ Regeneration Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Protein Localization To Kinetochore TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Response To Drug Negative Regulation Of Apoptotic Process Innate Immune Response Response To Ethanol Positive Regulation Of DNA Replication Positive Regulation Of Mitotic Cell Cycle Regulation Of Embryonic Development Response To Cadmium Ion Response To Copper Ion Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Response To Axon Injury Cell Division Stress-activated MAPK Cascade Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Cellular Response To Hydrogen Peroxide
Pathways		Oxidative Stress Induced Senescence Cellular Senescence Epigenetic regulation of gene expression PRC2 methylates histones and DNA	Phosphorylation of the APC/C Signaling by FGFR in disease Phosphorylation of Emi1 Signaling by EGFRvIII in Cancer Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome SOS-mediated signalling Mitotic G1-G1/S phases SHC-mediated signalling Recruitment of mitotic centrosome proteins and complexes TRIF-mediated TLR3/TLR4 signaling ERK1 activation Nuclear Pore Complex (NPC) Disassembly APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase ERK1 activation APC/C:Cdc20 mediated degradation of Cyclin B Signaling by VEGF Resolution of Sister Chromatid Cohesion Downstream signal transduction Signalling to RAS Toll Like Receptor 3 (TLR3) Cascade Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Interleukin-2 signaling Mitotic G2-G2/M phases Frs2-mediated activation MASTL Facilitates Mitotic Progression Axon guidance IRS-mediated signalling G2/M Transition VEGFA-VEGFR2 Pathway Activated TLR4 signalling VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling Cyclin A/B1 associated events during G2/M transition Loss of Nlp from mitotic centrosomes MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Condensation of Prometaphase Chromosomes Signaling by Insulin receptor E2F mediated regulation of DNA replication Insulin receptor signalling cascade Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes G0 and Early G1 Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) E2F-enabled inhibition of pre-replication complex formation Regulation of mitotic cell cycle Cell Cycle Checkpoints Signaling by GPCR G2/M Checkpoints Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization FCERI mediated MAPK activation Regulation of PLK1 Activity at G2/M Transition SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling G1/S Transition G1/S-Specific Transcription Toll Like Receptor 9 (TLR9) Cascade G2/M DNA replication checkpoint Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 APC/C-mediated degradation of cell cycle proteins Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Condensation of Prophase Chromosomes Signaling by Leptin Signalling to ERKs Mitotic Prometaphase Prolonged ERK activation events Organelle biogenesis and maintenance ERK activation Toll Like Receptor 7/8 (TLR7/8) Cascade Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Envelope Breakdown IGF1R signaling cascade Recruitment of NuMA to mitotic centrosomes Cyclin B2 mediated events Toll Like Receptor TLR6:TLR2 Cascade M Phase IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation Downstream signaling of activated FGFR Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Signalling by NGF SOS-mediated signalling G2/M DNA damage checkpoint MAP kinase activation in TLR cascade SHC-mediated signalling Depolymerisation of the Nuclear Lamina Assembly of the primary cilium Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic SHC1 events in EGFR signaling Loss of proteins required for interphase microtubule organizationÂ from the centrosome FRS2-mediated cascade IRS-mediated signalling Centrosome maturation
Drugs			Indirubin-3\'-Monoxime Olomoucine Hymenialdisine SU9516 Flavopiridol Alsterpaullone
Diseases
GWAS
Protein-Protein Interactions		64 interactors: AKT1 ATP1A1 ATP1B1 ATRX BRCA1 C7orf25 CCDC85B CDK1 CDK2 CDK6 CDKN2B-AS1 CEP63 DNAJB11 DNMT1 DNMT3A DNMT3B E2F6 EED EHMT1 EPC2 GADD45G GTF3C1 HDAC1 HIST1H1A HIST1H3A HIST3H3 HOTAIR JAK2 KDM1A KLHDC2 MAP3K7 MAPK8IP2 MAPKAPK3 MED1 NINL PFDN1 PHB2 PHF1 PIN4 PJA1 POLA2 PRMT5 PSMB6 RASA1 RBBP4 RBL2 RELA RELB RPN2 RPS6KA5 SMN1 SMS SMYD3 SUV39H1 SUZ12 TAF1D TK1 TNFSF11 USP7 VAV1 WDR61 WSB2 ZAK ZMYND11	174 interactors: ABL1 AMPH APLP2 AR ARID4A BCL2 BIRC5 BIRC6 BRCA1 BRCA2 BTRC BUB1 CALD1 CCNA1 CCNA2 CCNB1 CCNB2 CCNE1 CCP110 CD8A CDC25A CDC25B CDC25C CDC6 CDCA2 CDCA5 CDK7 CDKN1A CDKN3 CDT1 CEP55 CHAF1B CIITA CKS1B CKS2 CNOT7 CREM CSN2 CSNK2A1 CSNK2B CUX1 CXCR1 DAB2 DCTN6 DNM2 DUT E2F1 ECT2 EEF1D EEF2K EP300 EPN1 ERCC2 EZH2 FANCA FANCC FANCG FBXO5 FEN1 FOXM1 FYN FZR1 GADD45A GADD45B GADD45G GFAP GOLGA2 GORASP1 H1F0 HIST1H1A HIST1H1B HIST1H1D HIST1H2AB HIST1H2BB HIST1H4A HMGA1 HMGA2 HMGB1 HSPA2 HTRA2 IL16 IL3RA ITPR1 JAK3 KAT5 KHDRBS1 KIF11 KIF20B KIF26B KMT2E KRT18 LATS1 LMNA LMNB1 LYN LZTS1 MAP4 MAPT MARCKS MBP MCM4 MDM4 MEF2C MKI67 MLKL MNDA MYC MYT1 NCAPD2 NCAPG NCAPH NCL NDE1 NES NPM1 NSFL1C NUP210 PAK6 PBK PCNA PIN1 PITPNM1 PKMYT1 PLEC PML POLA1 PPP2R1A PPP2R1B PRC1 PTCH1 PTMA PTPN1 PTPN2 PTTG1 RAB4A RAB5B RACGAP1 RAP1GAP RB1 RCC1 RELB REPS2 RGCC RPA1 RPA2 RPS6KB1 RRM2 RUNX1 RUNX2 SFN SP1 SPAG5 SQSTM1 SSBP1 STMN1 STMN2 TFDP1 TGFBR2 TK1 TLE1 TNNC1 TOP2A TP53 TP53BP1 TP73 TSC1 TSPYL2 UBA1 UBE2A UHRF2 USP16 VIM WEE1 ZBTB16
Entrez ID		2146	983
HPRD ID		03342	00302
Ensembl ID		ENSG00000106462	ENSG00000170312
Uniprot IDs		Q15910 S4S3R8	B7Z3D6 I6L9I5 P06493
PDB IDs		2C6V 4MI0	1LC9
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Modification Chromosome Organization Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Organelle Organization Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Modification Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Modification Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Histone Methylation Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Histone Methylation Macromolecule Biosynthetic Process Methylation Cell Cycle Negative Regulation Of Histone Methylation Positive Regulation Of Histone Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Histone Modification Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Histone H3-K4 Methylation Intracellular Signal Transduction	Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Regulation Of Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Organelle Organization Cell Division Regulation Of Cell Cycle Process Mitotic Nuclear Division Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Cellular Response To Stress Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Regulation Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus DNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Kinase Activity Programmed Cell Death Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Apoptotic Process Cell Death Death Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Response To Stimulus Regulation Of Organelle Organization Negative Regulation Of Cell Cycle Developmental Process Regulation Of Cell Proliferation Regulation Of Cell Division Cellular Process Response To Stress Regulation Of Cellular Process Anatomical Structure Development Chromosome Organization Positive Regulation Of Gene Expression Response To Stimulus Cell Differentiation Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm eed esc fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste	137cs abundance accordingly alteration arrested caffeine cdk2 checkpoint constitutively culturing cytometry delayed diminished g2 hyperphosphorylation inactivation irradiated irradiation mcf monitored overexpressed pronounced qualities radiation regard scl unchanged uv whose
Tagcloud (Difference) ?		70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm eed esc fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste	137cs abundance accordingly alteration arrested caffeine cdk2 checkpoint constitutively culturing cytometry delayed diminished g2 hyperphosphorylation inactivation irradiated irradiation mcf monitored overexpressed pronounced qualities radiation regard scl unchanged uv whose
Tagcloud (Intersection) ?