EZH2 and ATP1A1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EZH2	ATP1A1
Gene Name		enhancer of zeste 2 polycomb repressive complex 2 subunit	ATPase, Na+/K+ transporting, alpha 1 polypeptide
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm ESC/E(Z) Complex Pronucleus	Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane T-tubule Vesicle Sarcolemma Melanosome Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Core Promoter Binding DNA Binding Chromatin Binding RNA Binding Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Chromatin DNA Binding Histone Methyltransferase Activity Sequence-specific DNA Binding Histone Methyltransferase Activity (H3-K27 Specific)	Sodium:potassium-exchanging ATPase Activity Protein Binding ATP Binding Phosphatase Activity Protein Kinase Binding Protein Domain Specific Binding Ankyrin Binding Potassium Ion Binding Sodium Ion Binding ADP Binding Phosphatidylinositol 3-kinase Binding Chaperone Binding Steroid Hormone Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Gliogenesis Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Cerebellar Cortex Development Positive Regulation Of Ras GTPase Activity Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Regulation Of Circadian Rhythm Positive Regulation Of MAP Kinase Activity Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Rhythmic Process Negative Regulation Of Striated Muscle Cell Differentiation Cellular Response To Hydrogen Peroxide G1 To G0 Transition Histone H3-K27 Methylation Protein Localization To Chromatin Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Regulation Of The Force Of Heart Contraction Regulation Of Sodium Ion Transport Cellular Sodium Ion Homeostasis Regulation Of Blood Pressure Potassium Ion Import Dephosphorylation Cellular Potassium Ion Homeostasis Negative Regulation Of Glucocorticoid Biosynthetic Process Ion Transmembrane Transport Sodium Ion Export From Cell Response To Drug Negative Regulation Of Heart Contraction Positive Regulation Of Heart Contraction Positive Regulation Of Striated Muscle Contraction Transmembrane Transport Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Membrane Hyperpolarization Cellular Response To Mechanical Stimulus Cellular Response To Steroid Hormone Stimulus Regulation Of Cardiac Muscle Cell Contraction Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Response To Glycoside
Pathways		Oxidative Stress Induced Senescence Cellular Senescence Epigenetic regulation of gene expression PRC2 methylates histones and DNA	Ion transport by P-type ATPases Ion channel transport
Drugs			Digoxin Acetyldigitoxin Hydroflumethiazide Ethacrynic acid Trichlormethiazide Deslanoside Ouabain Diazoxide Bretylium Bepridil Potassium Aluminium Magnesium Digitoxin Almitrine
Diseases
GWAS
Protein-Protein Interactions		64 interactors: AKT1 ATP1A1 ATP1B1 ATRX BRCA1 C7orf25 CCDC85B CDK1 CDK2 CDK6 CDKN2B-AS1 CEP63 DNAJB11 DNMT1 DNMT3A DNMT3B E2F6 EED EHMT1 EPC2 GADD45G GTF3C1 HDAC1 HIST1H1A HIST1H3A HIST3H3 HOTAIR JAK2 KDM1A KLHDC2 MAP3K7 MAPK8IP2 MAPKAPK3 MED1 NINL PFDN1 PHB2 PHF1 PIN4 PJA1 POLA2 PRMT5 PSMB6 RASA1 RBBP4 RBL2 RELA RELB RPN2 RPS6KA5 SMN1 SMS SMYD3 SUV39H1 SUZ12 TAF1D TK1 TNFSF11 USP7 VAV1 WDR61 WSB2 ZAK ZMYND11	14 interactors: A2M ADD1 CFL1 EGFR EZH2 FXYD1 FXYD2 FXYD7 HGS MAPK1 MAPK3 NDRG1 PRKCA TPT1
Entrez ID		2146	476
HPRD ID		03342	01662
Ensembl ID		ENSG00000106462	ENSG00000163399
Uniprot IDs		Q15910 S4S3R8	P05023
PDB IDs		2C6V 4MI0
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Modification Chromosome Organization Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Organelle Organization Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Histone Modification Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Modification Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Histone Methylation Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Histone Methylation Macromolecule Biosynthetic Process Methylation Cell Cycle Negative Regulation Of Histone Methylation Positive Regulation Of Histone Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Histone Modification Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Histone H3-K4 Methylation Intracellular Signal Transduction	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Activation Platelet Activation Regulation Of MAP Kinase Activity Response To Epidermal Growth Factor Wound Healing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Regulation Of Intracellular Signal Transduction Regulation Of Golgi Inheritance Positive Regulation Of Protein Phosphorylation Cell Differentiation Regulation Of Protein Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Caveolin-mediated Endocytosis Blood Coagulation Regulation Of Kinase Activity Hemostasis Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of MAPK Cascade Response To Fibroblast Growth Factor Positive Regulation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Activation Of MAPKK Activity Neurotrophin Signaling Pathway Regulation Of Golgi Organization Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Body Fluid Levels Fc Receptor Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Chemotaxis Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Cellular Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Stress Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport
Tagcloud ?		70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm eed esc fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste	aldosterone betamethasone breaths compliance corticosteroid corticosteroids elastin enac enacalpha enacbeta epithelia fetuses gestation gr inflation infused infusions intravenously mineralocorticoid mr ovine pressures reabsorption scnn1a scnn1b stepwise synergy transcriptomic
Tagcloud (Difference) ?		70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm eed esc fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste	aldosterone betamethasone breaths compliance corticosteroid corticosteroids elastin enac enacalpha enacbeta epithelia fetuses gestation gr inflation infused infusions intravenously mineralocorticoid mr ovine pressures reabsorption scnn1a scnn1b stepwise synergy transcriptomic
Tagcloud (Intersection) ?