TNFRSF25 and TRADD

Data Source:
HPRD (two hybrid, in vivo)

		TNFRSF25	TRADD
Description		TNF receptor superfamily member 25	TNFRSF1A associated via death domain
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GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane	Tumor Necrosis Factor Receptor Superfamily Complex Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Death-inducing Signaling Complex Receptor Complex Membrane Raft
	Molecular Function	Tumor Necrosis Factor-activated Receptor Activity Signaling Receptor Activity	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Tumor Necrosis Factor Receptor Binding Protein Binding Kinase Binding Identical Protein Binding Protein-containing Complex Binding Death Domain Binding
	Biological Process	Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Apoptotic Signaling Pathway	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cell Migration Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Hair Follicle Development Cellular Response To Tumor Necrosis Factor Death-inducing Signaling Complex Assembly Extrinsic Apoptotic Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		TNFs bind their physiological receptors	Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Regulation of necroptotic cell death Dimerization of procaspase-8 TNF signaling Defective RIPK1-mediated regulated necrosis
Drugs
Diseases
GWAS
Interacting Genes		8 interacting genes: BAG4 DAP3 MAPK1 TNFRSF1A TNFSF12 TNFSF15 TRADD TRAF2	24 interacting genes: APBB2 BCL10 BIRC2 CNTRL DAPK1 FADD FAS HIPK2 KRT14 KRT18 NGFR PPP2R1A RIPK1 STAT1 TMC8 TNFRSF10A TNFRSF10B TNFRSF1A TNFRSF21 TNFRSF25 TRAF1 TRAF2 TRAF3 TRPC4AP
Entrez ID		8718	8717
HPRD ID		04532	04610
Ensembl ID		ENSG00000215788	ENSG00000102871
Uniprot IDs		Q93038	Q15628
PDB IDs		5YGP 5YGS	1F2H 1F3V 5XME 6AC0
Enriched GO Terms of Interacting Partners?
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