OXSR1 and SLC12A1

Data Source:
HPRD (two hybrid)

		OXSR1	SLC12A1
Description		oxidative stress responsive kinase 1	solute carrier family 12 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Plasma Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Sodium:potassium:chloride Symporter Activity Potassium:chloride Symporter Activity
	Biological Process	Protein Phosphorylation Response To Oxidative Stress Signal Transduction Osmosensory Signaling Pathway Positive Regulation Of T Cell Chemotaxis Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Chemokine (C-C Motif) Ligand 21 Signaling Pathway Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Protein Autophosphorylation Cellular Hypotonic Response Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Cellular Response To Chemokine	Ion Transport Cell Volume Homeostasis Ion Transmembrane Transport Sodium Ion Transmembrane Transport Chloride Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways			Cation-coupled Chloride cotransporters Defective SLC12A1 causes Bartter syndrome 1 (BS1)
Drugs		Fostamatinib	Torasemide Methyclothiazide Chlorthalidone Chlormerodrin Furosemide Potassium chloride Hydroflumethiazide Bumetanide Etacrynic acid Quinethazone Piretanide
Diseases			Bartter syndrome
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494)	Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Metabolite levels (Pyroglutamine) ( 23934736) Monocyte count ( 32888494) Systemic lupus erythematosus ( 26606652)
Interacting Genes		10 interacting genes: APP BMPR1B PAK1 RELL1 RELL2 SLC12A1 SLC12A2 SLC12A6 SMURF1 TGFBR1	2 interacting genes: OXSR1 STK39
Entrez ID		9943	6557
HPRD ID		06809	02908
Ensembl ID		ENSG00000172939	ENSG00000074803
Uniprot IDs		O95747	B4DPF4 Q13621 Q8IUN5
PDB IDs		2V3S 2VWI 3DAK
Enriched GO Terms of Interacting Partners?
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