SMG7 and SMG5

Data Source:
HPRD (in vivo)

		SMG7	SMG5
Description		SMG7 nonsense mediated mRNA decay factor	SMG5 nonsense mediated mRNA decay factor
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GO Annotations	Cellular Component	Nucleus Telomerase Holoenzyme Complex Cytoplasm Cytosol Intermediate Filament Cytoskeleton	Nucleus Telomerase Holoenzyme Complex Cytoplasm Cytosol
	Molecular Function	Protein Binding Telomeric DNA Binding Protein Phosphatase 2A Binding Telomerase RNA Binding	Protein Binding Ubiquitin Protein Ligase Binding Telomeric DNA Binding Histone Deacetylase Binding Protein Phosphatase 2A Binding Telomerase RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Regulation Of Dephosphorylation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Dephosphorylation
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Initial pursuit acceleration ( 29064472) Systemic lupus erythematosus ( 27399966 26502338 28714469)	Glycated hemoglobin levels ( 29170429) Hemoglobin A1c levels ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010 20139978)
Interacting Genes		4 interacting genes: FGFR3 MDM2 SIRPA SMG5	7 interacting genes: APP SMG1 SMG6 SMG7 STUB1 TERT UPF1
Entrez ID		9887	23381
HPRD ID		10723	16869
Ensembl ID		ENSG00000116698	ENSG00000198952
Uniprot IDs		E9PD50 Q6TV06 Q92540	Q9UPR3
PDB IDs		1YA0	2HWY
Enriched GO Terms of Interacting Partners?
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