SMG5 and SMG7

Data Source:
HPRD (in vivo)

		SMG5	SMG7
Description		SMG5 nonsense mediated mRNA decay factor	SMG7 nonsense mediated mRNA decay factor
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GO Annotations	Cellular Component	Nucleus Telomerase Holoenzyme Complex Cytoplasm Cytosol	Nucleus Telomerase Holoenzyme Complex Cytoplasm Cytosol Intermediate Filament Cytoskeleton
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Telomeric DNA Binding Histone Deacetylase Binding Protein Phosphatase 2A Binding Telomerase RNA Binding	Protein Binding Telomeric DNA Binding Protein Phosphatase 2A Binding Telomerase RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Dephosphorylation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Regulation Of Dephosphorylation
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Glycated hemoglobin levels ( 29170429) Hemoglobin A1c levels ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010 20139978)	Initial pursuit acceleration ( 29064472) Systemic lupus erythematosus ( 27399966 26502338 28714469)
Interacting Genes		7 interacting genes: APP SMG1 SMG6 SMG7 STUB1 TERT UPF1	4 interacting genes: FGFR3 MDM2 SIRPA SMG5
Entrez ID		23381	9887
HPRD ID		16869	10723
Ensembl ID		ENSG00000198952	ENSG00000116698
Uniprot IDs		Q9UPR3	E9PD50 Q6TV06 Q92540
PDB IDs		2HWY	1YA0
Enriched GO Terms of Interacting Partners?
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