GINS1 and TOPBP1

Data Source:
BioGRID (two hybrid)

		GINS1	TOPBP1
Description		GINS complex subunit 1	DNA topoisomerase II binding protein 1
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GO Annotations	Cellular Component	GINS Complex Nucleus Nucleoplasm Cytoplasm CMG Complex	Condensed Nuclear Chromosome Spindle Pole Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Microtubule Organizing Center Plasma Membrane Actin Cytoskeleton Nuclear Body PML Body Intracellular Membrane-bounded Organelle
	Molecular Function		DNA Binding Protein Binding Protein C-terminus Binding Identical Protein Binding
	Biological Process	Inner Cell Mass Cell Proliferation DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Involved In Mitotic DNA Replication	DNA Metabolic Process DNA Replication DNA Replication Initiation DNA Repair Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Response To Ionizing Radiation Mitotic DNA Replication Checkpoint Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Unwinding of DNA Unwinding of DNA	HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Liver enzyme levels (alkaline phosphatase) ( 22001757) Platelet count ( 32888494) Telomere length ( 30185882)	Iron status biomarkers ( 19084217)
Interacting Genes		2 interacting genes: GINS4 TOPBP1	32 interacting genes: ABL1 AKT1 ATM BLM BMPR2 BRIP1 CDC45 CHEK1 CLSTN1 E2F1 ESR1 FHL3 GINS1 HUS1 PML POLE PPHLN1 PPP1CC RAD1 RAD9A RAI1 RBBP8 RHNO1 SF3B2 SMARCAD1 TBC1D4 TCFL5 TEX11 TICRR TOP2B UBR5 ZBTB17
Entrez ID		9837	11073
HPRD ID		11067	09678
Ensembl ID		ENSG00000101003	ENSG00000163781
Uniprot IDs		Q14691	A0AV47 A7E2X7 Q05BV8 Q92547
PDB IDs		2E9X 2EHO 2Q9Q 6XTX 6XTY	1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO 6RML 6RMM
Enriched GO Terms of Interacting Partners?
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