KEAP1 and MYO7A

Data Source:
HPRD (two hybrid, in vivo)

		KEAP1	MYO7A
Description		kelch like ECH associated protein 1	myosin VIIA
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Actin Filament Inclusion Body Midbody Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Lysosomal Membrane Cytosol Microvillus Cell Cortex Actin Cytoskeleton Apical Plasma Membrane Myosin VII Complex Vesicle Photoreceptor Connecting Cilium Stereocilium Melanosome Synapse Stereocilium Base Upper Tip-link Density
	Molecular Function	Protein Binding Transcription Factor Binding Identical Protein Binding Disordered Domain Specific Binding	Microfilament Motor Activity Protein Binding Calmodulin Binding ATP Binding Protein Domain Specific Binding Spectrin Binding Actin-dependent ATPase Activity Identical Protein Binding ADP Binding Protein N-terminus Binding Actin Filament Binding
	Biological Process	In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Viral Process Protein Ubiquitination Protein Deubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA-binding Transcription Factor Activity Post-translational Protein Modification Regulation Of Epidermal Cell Differentiation Cellular Response To Interleukin-4	Phagolysosome Assembly Intracellular Protein Transport Actin Filament Organization Lysosome Organization Sensory Organ Development Visual Perception Sensory Perception Of Sound Actin Filament-based Movement Vesicle Transport Along Actin Filament Cellular Protein Localization Eye Photoreceptor Cell Development Mechanoreceptor Differentiation Post-embryonic Animal Organ Morphogenesis Sensory Perception Of Light Stimulus Equilibrioception Pigment Granule Transport Auditory Receptor Cell Stereocilium Organization
Pathways		Ub-specific processing proteases Neddylation Antigen processing: Ubiquitination & Proteasome degradation	The canonical retinoid cycle in rods (twilight vision)
Drugs		Dimethyl fumarate
Diseases			Usher syndrome (US) Deafness, autosomal dominant Deafness, autosomal recessive
GWAS		Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)	Lewy body disease ( 25188341) Post bronchodilator FEV1/FVC ratio ( 26634245) Tourette syndrome ( 30818990)
Interacting Genes		77 interacting genes: AK4 AMER1 ANKS1A ATG5 BAD BPTF C2orf68 CARD10 CAT CCNB1IP1 CDH1 CDK6 CLU COL1A1 COL2A1 CPEB2 CSNK2A1 CTTN CUL3 DPP3 EAF1 EGFR ERICH5 ETF1 FAM117B GLRX5 GPR151 GYPA HSP90AA1 HSP90AB1 ICAM1 IFIH1 IPO11 IQCC IRF1 KLHL2 KLHL3 KPNA6 LAMTOR5 LSM3 MAD2L1 MAPKBP1 MCM3 MCMBP MYO7A NFE2L2 NIBAN2 NTAQ1 NUDT4 NUP50 OXR1 PALB2 PAQR4 PDCD6IP PPP1R13L PRKAG1 PTMA RAF1 RECK RELA SMARCD1 SNRPN SQSTM1 STAP2 STK3 STK4 TBC1D7 TENT5A TERF1 TET2 TRIM15 UBC USP15 WDR83 WHRN ZNF121 ZSCAN32	12 interacting genes: ACTA1 CALM1 CDH23 KEAP1 KHDRBS1 LINC00839 MAP2 MYRIP PRKAR1A USH1C VEZT WHRN
Entrez ID		9817	4647
HPRD ID		12079	02043
Ensembl ID		ENSG00000079999	ENSG00000137474
Uniprot IDs		A0A024R7C0 Q14145	Q13402
PDB IDs		1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4CXI 4CXJ 4CXT 4IFJ 4IFL 4IFN 4IN4 4IQK 4L7B 4L7C 4L7D 4N1B 4XMB 5DAD 5DAF 5F72 5GIT 5NLB 5WFL 5WFV 5WG1 5WHL 5WHO 5WIY 5X54 6FFM 6FMP 6FMQ 6HWS 6LRZ 6ROG 6SP1 6SP4 6T7V 6T7Z 6TG8 6TYM 6TYP 6UF0 6V6Z 6W66 6W67 6W68 6W69 6WCQ	5MV9
Enriched GO Terms of Interacting Partners?
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