KEAP1 and BPTF

Data Source:
BioGRID (pull down)
HPRD (two hybrid, in vivo, in vitro)

		KEAP1	BPTF
Description		kelch like ECH associated protein 1	bromodomain PHD finger transcription factor
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Actin Filament Inclusion Body Midbody Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite	Chromatin Nucleus Nucleoplasm Cytoplasm NURF Complex Dendrite Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Transcription Factor Binding Identical Protein Binding Disordered Domain Specific Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding DNA-dependent ATPase Activity Transcription Factor Binding Methylated Histone Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Viral Process Protein Ubiquitination Protein Deubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA-binding Transcription Factor Activity Post-translational Protein Modification Regulation Of Epidermal Cell Differentiation Cellular Response To Interleukin-4	Negative Regulation Of Transcription By RNA Polymerase II Embryonic Placenta Development Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Brain Development Endoderm Development Response To Wounding Anterior/posterior Pattern Specification Nucleosome Mobilization Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Nerve Growth Factor Stimulus
Pathways		Ub-specific processing proteases Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Dimethyl fumarate
Diseases
GWAS		Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)	Adult body size ( 32376654) Alcohol dependence symptom count ( 27151647) Apolipoprotein B levels ( 32203549) Body mass index ( 28892062) Brain morphology (MOSTest) ( 32665545) EGFR mutation-positive lung adenocarcinoma ( 27501781) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Hand grip strength ( 29691431) HDL cholesterol ( 30275531) Height ( 31562340) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Lung adenocarcinoma ( 22797724) Lung cancer ( 23143601) Macular thickness ( 30535121) Metabolic syndrome ( 31589552) Neutrophil percentage of granulocytes ( 27863252) Non-small cell lung cancer ( 31326317) Psoriasis ( 25854761) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Sum eosinophil basophil counts ( 27863252) Triglyceride levels ( 32203549 32154731) Type 2 diabetes ( 30297969)
Interacting Genes		77 interacting genes: AK4 AMER1 ANKS1A ATG5 BAD BPTF C2orf68 CARD10 CAT CCNB1IP1 CDH1 CDK6 CLU COL1A1 COL2A1 CPEB2 CSNK2A1 CTTN CUL3 DPP3 EAF1 EGFR ERICH5 ETF1 FAM117B GLRX5 GPR151 GYPA HSP90AA1 HSP90AB1 ICAM1 IFIH1 IPO11 IQCC IRF1 KLHL2 KLHL3 KPNA6 LAMTOR5 LSM3 MAD2L1 MAPKBP1 MCM3 MCMBP MYO7A NFE2L2 NIBAN2 NTAQ1 NUDT4 NUP50 OXR1 PALB2 PAQR4 PDCD6IP PPP1R13L PRKAG1 PTMA RAF1 RECK RELA SMARCD1 SNRPN SQSTM1 STAP2 STK3 STK4 TBC1D7 TENT5A TERF1 TET2 TRIM15 UBC USP15 WDR83 WHRN ZNF121 ZSCAN32	10 interacting genes: H3-3A H3-4 H4C9 KEAP1 MAZ NFE2L2 SMAD2 SMAD3 SQSTM1 SUMO2
Entrez ID		9817	2186
HPRD ID		12079	03490
Ensembl ID		ENSG00000079999	ENSG00000171634
Uniprot IDs		A0A024R7C0 Q14145	Q12830
PDB IDs		1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4CXI 4CXJ 4CXT 4IFJ 4IFL 4IFN 4IN4 4IQK 4L7B 4L7C 4L7D 4N1B 4XMB 5DAD 5DAF 5F72 5GIT 5NLB 5WFL 5WFV 5WG1 5WHL 5WHO 5WIY 5X54 6FFM 6FMP 6FMQ 6HWS 6LRZ 6ROG 6SP1 6SP4 6T7V 6T7Z 6TG8 6TYM 6TYP 6UF0 6V6Z 6W66 6W67 6W68 6W69 6WCQ	2F6J 2F6N 2FSA 2FUI 2FUU 2RI7 3QZS 3QZT 3QZV 3UV2 5H6Y 5R4G 5R4H 5R4I 5R4J 5R4K 5R4L 5R4M 5R4N 5R4O 6AZE
Enriched GO Terms of Interacting Partners?
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