EEA1 and RAB22A

Data Source:
HPRD (two hybrid, in vitro)

		EEA1	RAB22A
Description		early endosome antigen 1	RAB22A, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Early Endosome Cytosol Serine-pyruvate Aminotransferase Complex Membrane Extrinsic Component Of Plasma Membrane Early Endosome Membrane Axonal Spine Recycling Endosome Extracellular Exosome	Ruffle Early Endosome Late Endosome Plasma Membrane Endosome Membrane Endomembrane System Actin Cytoskeleton Phagocytic Vesicle Membrane Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Endocytosis Vesicle Fusion Synaptic Vesicle To Endosome Fusion Viral RNA Genome Replication Early Endosome To Late Endosome Transport	Intracellular Protein Transport Endocytosis Endosome Organization Regulation Of Vesicle Size
Pathways		Toll Like Receptor 9 (TLR9) Cascade	RAB geranylgeranylation
Drugs		Inositol 1,3-Bisphosphate
Diseases
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Sensorimotor dexterity ( 31596458) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Western dietary pattern ( 28644415)	Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) Metabolite levels ( 23823483) Nickel levels ( 26025379)
Interacting Genes		13 interacting genes: IGF1R MAPK14 RAB22A RAB31 RAB5A RAB5B RAB5C RRAD STX12 STX6 TOM1 USO1 ZFYVE16	7 interacting genes: ALS2CL APPL2 EEA1 RAB3GAP1 RAB7A RABAC1 SMURF2
Entrez ID		8411	57403
HPRD ID		05460	06696
Ensembl ID		ENSG00000102189	ENSG00000124209
Uniprot IDs		Q15075	Q9UL26
PDB IDs		1HYI 1HYJ 1JOC 3MJH
Enriched GO Terms of Interacting Partners?
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