SART3 and C6

Data Source:
BioGRID (two hybrid)

		SART3	C6
Description		spliceosome associated factor 3, U4/U6 recycling protein	complement C6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm U6atac SnRNP Cytoplasm Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex ASAP Complex U4/U6 SnRNP U4atac/U6atac SnRNP	Extracellular Region Membrane Attack Complex Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding U6 SnRNA Binding U4 SnRNA Binding U6atac SnRNA Binding Histone Binding Ubiquitin-specific Protease Binding	Protein Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Nucleosome Assembly Regulation Of Gene Expression Positive Regulation Of Histone Deubiquitination	In Utero Embryonic Development Complement Activation Complement Activation, Classical Pathway Cytolysis Regulation Of Complement Activation Innate Immune Response
Pathways			Terminal pathway of complement Regulation of Complement cascade
Drugs
Diseases		Disseminated superficial actinic porokeratosis (DSAP)	Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		Acne (severe) ( 24927181)	Blood protein levels ( 28240269) Refractive error ( 32231278) Response to fenofibrate (adiponectin levels) ( 23149075)
Interacting Genes		29 interacting genes: AR C6 COIL H2AC20 H2BC21 KPNA2 LSM7 MEGF10 MIR1-1 MIR128-2 MIR143 MIR18A MIR18B MIR19B2 MIR200B MIR200C MIR221 MIR34A MIR34B MIR7-1 MIR7-3 MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 PRPF3 RNPS1 ZNF620 ZNF71	4 interacting genes: C5 F2 OGA SART3
Entrez ID		9733	729
HPRD ID		11532	01956
Ensembl ID		ENSG00000075856	ENSG00000039537
Uniprot IDs		A0A499FI31 Q15020	P13671
PDB IDs		2DO4 5CTQ 5CTR 5CTT 5JJW 5JJX 5JPZ	3T5O 4A5W 4E0S 6H03 6H04
Enriched GO Terms of Interacting Partners?
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