ESPL1 and USP28

Data Source:
BioGRID (enzymatic study)

		ESPL1	USP28
Description		extra spindle pole bodies like 1, separase	ubiquitin specific peptidase 28
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Mitotic Spindle	Nucleus Nucleoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	Catalytic Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Meiotic Spindle Organization Mitotic Cytokinesis Proteolysis Apoptotic Process Establishment Of Mitotic Spindle Localization Homologous Chromosome Segregation Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Sister Chromatid Cohesion Meiotic Chromosome Separation	DNA Damage Checkpoint DNA Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Ras Protein Signal Transduction Cell Population Proliferation Response To Ionizing Radiation Protein Deubiquitination Protein Phosphopantetheinylation Regulation Of Protein Stability Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways		Separation of Sister Chromatids	Ub-specific processing proteases
Drugs
Diseases
GWAS		Femoral neck bone mineral density ( 29499414) Lumbar spine bone mineral density ( 29499414)	Alcohol consumption (drinks per week) ( 30643258) Low density lipoprotein cholesterol levels ( 32154731) PR interval ( 32439900)
Interacting Genes		7 interacting genes: MTNR1B PJA1 RFFL TRIM55 TRIM63 USP21 USP28	40 interacting genes: ATXN3L BAP1 CLSPN ESPL1 HIF1A JOSD1 KDM1A MAP3K1 MDC1 MTNR1A NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A PRKD1 RFFL SENP1 SENP8 STAM STAMBP SUMO2 TP53 TP53BP1 TRIM55 TRIM63 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8
Entrez ID		9700	57646
HPRD ID		06825	15632
Ensembl ID		ENSG00000135476	ENSG00000048028
Uniprot IDs		Q14674	B4E3L3 Q96RU2
PDB IDs			2LVA 2MUU 6H4H 6H4I 6HEH 6HEI 6HEJ 6HEK
Enriched GO Terms of Interacting Partners?
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