DEPDC5 and CCT3

Data Source:
BioGRID (two hybrid)

		DEPDC5	CCT3
Description		DEP domain containing 5, GATOR1 subcomplex subunit	chaperonin containing TCP1 subunit 3
Image
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Cytosol Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm GATOR1 Complex	Zona Pellucida Receptor Complex Cytosol Chaperonin-containing T-complex Cytoskeleton Microtubule Cell Body Extracellular Exosome
	Molecular Function	GTPase Activator Activity Protein-containing Complex Binding	RNA Binding Protein Binding ATP Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	Regulation Of Autophagy Negative Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Intracellular Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of TORC1 Signaling	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Pore Complex Assembly Protein Stabilization Toxin Transport Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		Amino acids regulate mTORC1	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs			Phosphoaminophosphonic Acid-Adenylate Ester Artenimol
Diseases
GWAS		Age-related hearing impairment ( 24939585) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Chronic hepatitis C infection ( 21725309) Fish- and plant-related diet ( 32066663) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence ( 22449649) Isthmus-cingulate cortex volume ( 31530798) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Type 2 diabetes ( 30130595)	Basophil count ( 32888494) Glycated hemoglobin levels ( 24647736) Household income (MTAG) ( 31844048) Mean corpuscular hemoglobin concentration ( 20139978) Mean corpuscular volume ( 29403010) Red blood cell count ( 29403010) Red cell distribution width ( 32888494) Subcutaneous adipose tissue ( 22589738)
Interacting Genes		10 interacting genes: CCT3 DPPA3 MAD2L1 MAD2L2 MEOX2 MTMR9 RRAGB RRAGC SYT17 USP2	24 interacting genes: BUD31 DEPDC5 EIF2B2 ERBB2 FANCA GEMIN4 HNRNPA0 HSPA8 LINC01554 LNX2 MAPK6 MIPOL1 PAFAH1B2 PDCL POLR1C PTEN RAF1 SH3BP4 SUMO2 UBE2Z VAV2 VHL XRCC6 ZNRD2
Entrez ID		9681	7203
HPRD ID		16795	08969
Ensembl ID		ENSG00000100150	ENSG00000163468
Uniprot IDs		O75140	B3KX11 P49368 Q59H77
PDB IDs		6CES 6CET	6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8
Enriched GO Terms of Interacting Partners?
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