SAFB2 and FNTA

Data Source:
BioGRID (two hybrid)

		SAFB2	FNTA
Description		scaffold attachment factor B2	farnesyltransferase, CAAX box, alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body Intracellular Membrane-bounded Organelle Extracellular Exosome	Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane CAAX-protein Geranylgeranyltransferase Complex Protein Farnesyltransferase Complex
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding Sequence-specific DNA Binding	Protein Farnesyltransferase Activity Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Rab Geranylgeranyltransferase Activity Protein Binding Microtubule Binding Acetylcholine Receptor Regulator Activity Receptor Tyrosine Kinase Binding Alpha-tubulin Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Processing Sertoli Cell Differentiation Regulation Of Androgen Receptor Signaling Pathway	Transforming Growth Factor Beta Receptor Signaling Pathway Protein Phosphopantetheinylation Protein Farnesylation Protein Geranylgeranylation Regulation Of Rhodopsin Mediated Signaling Pathway Neurotransmitter Receptor Metabolic Process Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Tubulin Deacetylation Positive Regulation Of Deacetylase Activity Regulation Of Neurotransmitter Receptor Activity
Pathways			Apoptotic cleavage of cellular proteins Inactivation, recovery and regulation of the phototransduction cascade RAS processing
Drugs			AZD3409 Lonafarnib 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE L-778123 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Farnesyl diphosphate Geranylgeranyl diphosphate ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
Diseases
GWAS		Creativity ( 32133506) Obsessive-compulsive symptoms ( 26859814) vWF and FVIII levels ( 21810271)	Zinc levels ( 26025379)
Interacting Genes		11 interacting genes: CHGB ERBB2 ESR1 FNTA FUS GIT2 SAFB SIRPA SORBS3 SUMO2 ZSCAN18	19 interacting genes: ACVR1 AP4M1 CENPF FNTB GBP1 HDAC6 HRAS INHBB KRAS PGGT1B PTP4A3 RHOB RPL13A SAFB2 STAT2 TGFB1 TGFBR1 TGM2 VAV2
Entrez ID		9667	2339
HPRD ID		06424	00607
Ensembl ID		ENSG00000130254	ENSG00000168522
Uniprot IDs		Q14151	P49354
PDB IDs			1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37
Enriched GO Terms of Interacting Partners?
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