FNTA and STAT2

Data Source:
BioGRID (two hybrid)

		FNTA	STAT2
Description		farnesyltransferase, CAAX box, alpha	signal transducer and activator of transcription 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane CAAX-protein Geranylgeranyltransferase Complex Protein Farnesyltransferase Complex	Chromatin Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Farnesyltransferase Activity Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Rab Geranylgeranyltransferase Activity Protein Binding Microtubule Binding Acetylcholine Receptor Regulator Activity Receptor Tyrosine Kinase Binding Alpha-tubulin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Ubiquitin-like Protein Ligase Binding
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Protein Phosphopantetheinylation Protein Farnesylation Protein Geranylgeranylation Regulation Of Rhodopsin Mediated Signaling Pathway Neurotransmitter Receptor Metabolic Process Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Tubulin Deacetylation Positive Regulation Of Deacetylase Activity Regulation Of Neurotransmitter Receptor Activity	Regulation Of Protein Phosphorylation Regulation Of Transcription By RNA Polymerase II Defense Response Receptor Signaling Pathway Via JAK-STAT Viral Process Cytokine-mediated Signaling Pathway Regulation Of Cell Population Proliferation Response To Peptide Hormone Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Mitochondrial Fission
Pathways		Apoptotic cleavage of cellular proteins Inactivation, recovery and regulation of the phototransduction cascade RAS processing	Interleukin-20 family signaling Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling Potential therapeutics for SARS
Drugs		AZD3409 Lonafarnib 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE L-778123 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Farnesyl diphosphate Geranylgeranyl diphosphate ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
Diseases
GWAS		Zinc levels ( 26025379)	Axial length ( 24144296) Height ( 20881960 25429064 23456168) Inflammatory skin disease ( 25574825) Lymphocyte percentage of white cells ( 32888494) Macular thickness ( 30535121) Psoriasis ( 25903422 25574825 23143594 19169254) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Refractive error ( 32231278)
Interacting Genes		19 interacting genes: ACVR1 AP4M1 CENPF FNTB GBP1 HDAC6 HRAS INHBB KRAS PGGT1B PTP4A3 RHOB RPL13A SAFB2 STAT2 TGFB1 TGFBR1 TGM2 VAV2	22 interacting genes: AURKA CREBBP CXCR4 DOK4 EGFR EP300 FNTA GAA GSK3A GSK3B HDAC1 IFNAR1 IFNAR2 IRF9 IWS1 JAK1 JAK2 MED14 SMARCA4 STAT1 STAT6 TYK2
Entrez ID		2339	6773
HPRD ID		00607	02778
Ensembl ID		ENSG00000168522	ENSG00000170581
Uniprot IDs		P49354	P52630 R9QE65
PDB IDs		1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37	2KA4 6UX2 6WCZ
Enriched GO Terms of Interacting Partners?
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