SH3PXD2A and AFAP1L2

Data Source:
BioGRID (pull down, affinity chromatography technology)

		SH3PXD2A	AFAP1L2
Description		SH3 and PX domains 2A	actin filament associated protein 1 like 2
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GO Annotations	Cellular Component	Podosome Cytoplasm Cytosol Cell Junction Cell Projection	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protease Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-5-phosphate Binding Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3,4-bisphosphate Binding Molecular Adaptor Activity Phosphatidylinositol-4-phosphate Binding	SH3 Domain Binding Protein Tyrosine Kinase Activator Activity Signaling Adaptor Activity SH2 Domain Binding
	Biological Process	In Utero Embryonic Development Superoxide Metabolic Process Extracellular Matrix Organization Regulation Of Catalytic Activity Osteoclast Fusion	Inflammatory Response Regulation Of Mitotic Cell Cycle Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Tyrosine Kinase Activity
Pathways		Invadopodia formation
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416818 28416822 29290336 29892015) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Cutaneous malignant melanoma ( 26237428) Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Intraocular pressure ( 29617998) Ischemic stroke ( 29531354) Ischemic stroke (small-vessel) ( 29531354) Manganese levels ( 26025379) Periventricular white matter hyperintensities ( 32517579) PR interval ( 30046033 32439900) Refractive error ( 32231278) Rheumatoid arthritis ( 30891314) Stroke ( 29531354) Waist circumference adjusted for body mass index ( 28552196) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218)	Cognitive performance ( 20125193) Left ventricular obstructive tract defect (maternal effect) ( 28468790) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Platelet distribution width ( 32888494) Systolic blood pressure ( 29212154)
Interacting Genes		7 interacting genes: ADAM15 AFAP1L2 FASLG KHDRBS1 PAK2 SRC SVIL	10 interacting genes: ACD APP ATXN1L POT1 RASA1 SH3PXD2A SRC TERF1 TERF2 TINF2
Entrez ID		9644	84632
HPRD ID		10228	13902
Ensembl ID		ENSG00000107957	ENSG00000169129
Uniprot IDs		B3KPL1 Q5TCZ1	B7Z2Q0 Q8N4X5
PDB IDs		2DNU 2EGA 2EGC 2EKH	2COF
Enriched GO Terms of Interacting Partners?
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