IKBKE and SIKE1

Data Source:
HPRD (two hybrid, in vivo)

		IKBKE	SIKE1
Description		inhibitor of nuclear factor kappa B kinase subunit epsilon	suppressor of IKBKE 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane PML Body Mitochondrial Membrane	Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Protein Phosphatase Binding Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Binding Protein Kinase Binding Small GTPase Binding
	Biological Process	Protein Phosphorylation Immune Response I-kappaB Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Lipid Storage Viral Process Peptidyl-serine Phosphorylation Negative Regulation Of Type I Interferon Production Response To Type I Interferon Response To Interferon-beta TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Virus
Pathways		SUMOylation of immune response proteins TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation
Drugs		Fostamatinib
Diseases
GWAS		Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Psoriasis ( 28537254) Systemic lupus erythematosus ( 27399966)
Interacting Genes		22 interacting genes: AZI2 BIRC2 BIRC3 CDC37 CHUK CYLD DDX3X FKBP5 HSP90AA1 HSP90AB1 IRF3 IRF5 KTN1 MBP NFKBIA RELA RIPK1 SIKE1 TANK TICAM1 TRIM27 XIAP	13 interacting genes: CBFA2T2 CENPQ CTAG1A CTAG1B IKBKE NTAQ1 SCOC STRN3 STX11 TBK1 TXLNA TXLNB ZC2HC1C
Entrez ID		9641	80143
HPRD ID		05442	07958
Ensembl ID		ENSG00000263528	ENSG00000052723
Uniprot IDs		A0A075B7B4 Q14164	Q9BRV8
PDB IDs			6AKK 6AKL 6AKM
Enriched GO Terms of Interacting Partners?
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