KLK4 and SHBG

Data Source:
HPRD (two hybrid)

		KLK4	SHBG
Description		kallikrein related peptidase 4	sex hormone binding globulin
Image
GO Annotations	Cellular Component	Extracellular Region Secretory Granule	Extracellular Region Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity Metal Ion Binding	Steroid Binding Androgen Binding Protein Binding
	Biological Process	Proteolysis Extracellular Matrix Disassembly Biomineral Tissue Development Amelogenesis
Pathways
Drugs			Masoprocol Diethylstilbestrol Levonorgestrel Progesterone Spironolactone Toremifene Estrone Tamoxifen Clomifene Dienestrol Hesperetin Zinc Genistein Naringenin Quercetin 4'-Hydroxyflavanone Afimoxifene Estriol Phenolphthalein Norethynodrel Dioxybenzone Zeranol Gestrinone Equol Zinc acetate Zinc chloride Zinc sulfate, unspecified form Estriol tripropionate
Diseases		Amelogenesis imperfecta
GWAS		Celiac disease ( 23936387) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Obesity-related traits ( 23251661)	Androgen levels ( 22936694) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Hormone measurements ( 24049095) Medication use (calcium channel blockers) ( 31015401) Protein quantitative trait loci ( 18464913) Red cell distribution width ( 27863252) Refractive error ( 32231278) Sex hormone levels ( 26014426) Sex hormone-binding globulin levels ( 22675492 22829776) Testosterone levels ( 21998597) Uterine fibroids ( 31649266)
Interacting Genes		3 interacting genes: SERPINA3 SHBG TYRO3	62 interacting genes: A2M ACP3 ACTA2 ACTB ACTG2 AK2 AKR1B1 AP1B1 AP2A1 APEH APOBEC3C APOD ASB16-AS1 ATP5F1A AZGP1 C9orf24 CD177 CEP192 CLDN4 CLEC4G COL1A2 CTSD DDX3Y DES DSTN EEF1A1 EIF3E EIF3F FLNA FLOT1 FYTTD1 GRB2 HDHD5 HYI JMJD7-PLA2G4B KLK4 MPDU1 MT1F MT1G MT2A MXD4 NOMO1 PACSIN2 PKM PLA2G4A PLP2 PSTPIP1 PSTPIP2 PTGDS RMND5B SEMA3F SLC37A1 SLC37A4 SNAPIN SNRNP70 SORD SRF SRI TINAGL1 UBE2O UBE3A ZC3H12A
Entrez ID		9622	6462
HPRD ID		04793	01646
Ensembl ID		ENSG00000167749	ENSG00000129214
Uniprot IDs		A0A0C4DFQ5 Q5BQA0 Q96PT1 Q9Y5K2	B0FWH2 B0FWH8 B4DYU0 I3L145 P04278
PDB IDs		2BDG 2BDH 2BDI 4K1E 4K8Y 4KEL 4KGA 6KBR 6NVB 6O21	1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW 6PYA 6PYB 6PYF 6ULB
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?