Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
RNF14 and NR3C1
Data Source:
HPRD
(in vivo, in vitro)
RNF14
NR3C1
Description
ring finger protein 14
nuclear receptor subfamily 3 group C member 1
Image
No pdb structure
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrial Matrix
Microtubule Organizing Center
Spindle
Cytosol
Nuclear Speck
Protein-containing Complex
Molecular Function
Transcription Coactivator Activity
Protein Binding
Ubiquitin-like Protein Transferase Activity
Ubiquitin Conjugating Enzyme Binding
Metal Ion Binding
Androgen Receptor Binding
Ubiquitin Protein Ligase Activity
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Core Promoter Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
RNA Binding
Nuclear Receptor Activity
Glucocorticoid Receptor Activity
Steroid Binding
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Hsp90 Protein Binding
Steroid Hormone Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Protein Polyubiquitination
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Signal Transduction
Protein Ubiquitination
Protein Phosphopantetheinylation
Androgen Receptor Signaling Pathway
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Transcription, DNA-templated
Regulation Of Androgen Receptor Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Apoptotic Process
Cell Cycle
Chromosome Segregation
Signal Transduction
Intracellular Steroid Hormone Receptor Signaling Pathway
Glucocorticoid Receptor Signaling Pathway
Glucocorticoid Mediated Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Cell Division
Cellular Response To Steroid Hormone Stimulus
Cellular Response To Glucocorticoid Stimulus
Cellular Response To Dexamethasone Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Circadian Clock
SUMOylation of intracellular receptors
PTK6 Expression
Regulation of RUNX2 expression and activity
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Potential therapeutics for SARS
Drugs
Flunisolide
Diflorasone
Alclometasone
Medrysone
Amcinonide
Fluorometholone
Megestrol acetate
Levonorgestrel
Beclomethasone dipropionate
Progesterone
Spironolactone
Betamethasone
Desoximetasone
Fluticasone propionate
Fluocinolone acetonide
Ulobetasol
Triamcinolone
Prednisone
Flumethasone
Fludrocortisone
Norethisterone
Hydrocortisone
Mometasone
Hydrocortamate
Mifepristone
Clocortolone
Flurandrenolide
Prednisolone
Loteprednol etabonate
Rimexolone
Methylprednisolone
Clobetasol propionate
Fluocinonide
Prednicarbate
Fluoxymesterone
Budesonide
Dexamethasone
Desonide
Cortisone acetate
Paramethasone
Drospirenone
Ciclesonide
Hexane-1,6-Diol
Aldosterone
ORG-34517
Difluprednate
Ulipristal
Fluticasone furoate
Tixocortol
Difluocortolone
Gestrinone
Deflazacort
Onapristone
Cortivazol
Clobetasone
Fluticasone
Mometasone furoate
Hydrocortisone aceponate
Hydrocortisone acetate
Hydrocortisone butyrate
Hydrocortisone cypionate
Hydrocortisone phosphate
Hydrocortisone probutate
Hydrocortisone valerate
Segesterone acetate
Prednisolone phosphate
Dexamethasone acetate
Betamethasone phosphate
Prednisolone acetate
Diseases
46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency
GWAS
Asthma (
31959851
)
Superior temporal gyrus volume (
31530798
)
Atrial fibrillation (
30061737
29892015
)
Lymphocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Night sleep phenotypes (
27126917
)
PR interval (
32439900
)
Spatial processing (
31596458
)
Interacting Genes
23 interacting genes:
AR
DACH1
ESR1
HNF1A
HNRNPA1
NCOA4
NR3C1
PHF7
TAGLN
TENT5A
TNFAIP3
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2L3
UBE2U
UBE2V1
UBE2W
VDR
160 interacting genes:
ABCC1
ADA
AR
ARPC5
BAG1
C1orf94
CALM1
CALR
CEBPA
CEBPB
CENPB
CHD9
COPS6
CREB1
CREBBP
DAP3
DAPK1
DCAF6
DDX54
DNMT3L
DOCK3
DTD1
ECD
EFHC2
EGFR
EPB41L1
ETS1
ETS2
FAM161B
FKBP4
FTH1
FYN
GNB1
GNB2
GRIP1
H3C1
HDAC1
HDAC6
HMGB1
HMGB2
HMOX2
HNRNPA1
HNRNPU
HSP90AA1
HSP90AB1
HSPA1A
HSPD1
IDE
IFNGR2
JUN
KAT5
KDM5A
KPNA2
KRTCAP3
LCK
LPXN
LRIF1
MAFF
MAPK1
MAPK15
MAPK8
MDM2
MED1
MED14
MED25
MSX2
NCL
NCOA1
NCOA2
NCOA3
NCOA4
NCOA6
NCOR1
NCOR2
NEDD4L
NFKB1
NFKB2
NR0B1
NR0B2
NR1H3
NR2E3
NR2F2
NR2F6
NR3C2
NR4A1
NRIP1
NUP54
ONECUT1
OSGEP
PBX1
PELP1
PIAS2
PML
POLR1D
POU1F1
POU2F1
POU2F2
PPARGC1A
PRDX3
PRKACA
PRKDC
PRPF6
PSMC3IP
PTGES3
PTMS
RACK1
RAD54L2
RAD9A
RAF1
RAN
RARA
RBM14
RELA
RFPL2
RNF14
RXRB
SFN
SGTA
SHKBP1
SLC25A4
SMAD3
SMARCA2
SMARCA4
SMARCB1
SMARCC1
SMARCD1
SMARCE1
SPIN2A
SRA1
SRC
STAT3
STAT5A
STAT5B
STRN3
STUB1
SUMO1
SUMO4
SVIL
SYT1
TADA2A
TBP
TDG
TGFB1I1
TMF1
TNS4
TP53
TRIM24
TRIM28
TSG101
TXN
UBB
UBE2I
UBE2L3
WTIP
YWHAH
ZBTB16
ZBTB20
ZBTB3
ZBTB9
ZNF496
Entrez ID
9604
2908
HPRD ID
05745
00679
Ensembl ID
ENSG00000013561
ENSG00000113580
Uniprot IDs
B7Z229
Q9UBS8
B7Z7I2
E5KQF5
E5KQF6
F1D8N4
P04150
PDB IDs
1M2Z
1NHZ
1P93
3BQD
3CLD
3E7C
3H52
3K22
3K23
4CSJ
4HN5
4HN6
4LSJ
4MDD
4P6W
4P6X
4UDC
4UDD
5CBX
5CBY
5CBZ
5CC1
5E69
5E6A
5E6B
5E6C
5E6D
5EMC
5EMP
5EMQ
5G3J
5G5W
5NFP
5NFT
5UC3
5VA0
5VA7
6BQU
6CFN
6DXK
6EL6
6EL7
6EL9
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?