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NR3C1 and MED1
Data Source:
BioGRID
(proximity labelling technology, pull down)
NR3C1
MED1
Description
nuclear receptor subfamily 3 group C member 1
mediator complex subunit 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrial Matrix
Microtubule Organizing Center
Spindle
Cytosol
Nuclear Speck
Protein-containing Complex
Ubiquitin Ligase Complex
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Membrane
Mediator Complex
Protein-DNA Complex
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Core Promoter Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
RNA Binding
Nuclear Receptor Activity
Glucocorticoid Receptor Activity
Steroid Binding
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Hsp90 Protein Binding
Steroid Hormone Binding
Sequence-specific Double-stranded DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Chromatin Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Transcription Factor Binding
Nuclear Receptor Binding
Estrogen Receptor Binding
Nuclear Receptor Coactivator Activity
Chromatin DNA Binding
Nuclear Hormone Receptor Binding
Vitamin D Receptor Binding
Retinoic Acid Receptor Binding
Peroxisome Proliferator Activated Receptor Binding
Protein-containing Complex Binding
Thyroid Hormone Receptor Binding
LBD Domain Binding
Ubiquitin Protein Ligase Activity
Promoter-specific Chromatin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Apoptotic Process
Cell Cycle
Chromosome Segregation
Signal Transduction
Intracellular Steroid Hormone Receptor Signaling Pathway
Glucocorticoid Receptor Signaling Pathway
Glucocorticoid Mediated Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Cell Division
Cellular Response To Steroid Hormone Stimulus
Cellular Response To Glucocorticoid Stimulus
Cellular Response To Dexamethasone Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Negative Regulation Of Transcription By RNA Polymerase II
Cell Morphogenesis
Angiogenesis
Liver Development
Embryonic Placenta Development
Lens Development In Camera-type Eye
Thyroid Hormone Mediated Signaling Pathway
Ventricular Trabecula Myocardium Morphogenesis
Retinal Pigment Epithelium Development
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Thyroid Hormone Generation
Protein Import Into Nucleus
Androgen Biosynthetic Process
Brain Development
Lactation
Positive Regulation Of Gene Expression
Negative Regulation Of Keratinocyte Proliferation
Protein Ubiquitination
Regulation Of Lipid Metabolic Process
Keratinocyte Differentiation
Monocyte Differentiation
Intracellular Steroid Hormone Receptor Signaling Pathway
Animal Organ Regeneration
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Embryonic Heart Tube Development
Embryonic Hindlimb Morphogenesis
Embryonic Hemopoiesis
Peroxisome Proliferator Activated Receptor Signaling Pathway
Cellular Response To Hepatocyte Growth Factor Stimulus
Megakaryocyte Development
MRNA Transcription By RNA Polymerase II
Negative Regulation Of Apoptotic Process
Fat Cell Differentiation
Positive Regulation Of Keratinocyte Differentiation
Positive Regulation Of Erythrocyte Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Erythrocyte Development
Enucleate Erythrocyte Development
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Interferon-gamma-mediated Signaling Pathway
Mammary Gland Branching Involved In Thelarche
Mammary Gland Branching Involved In Pregnancy
Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation
Positive Regulation Of G0 To G1 Transition
Regulation Of Vitamin D Receptor Signaling Pathway
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Steroid Hormone Stimulus
Cellular Response To Thyroid Hormone Stimulus
Positive Regulation Of Hepatocyte Proliferation
Regulation Of RNA Biosynthetic Process
Pathways
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Circadian Clock
SUMOylation of intracellular receptors
PTK6 Expression
Regulation of RUNX2 expression and activity
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Potential therapeutics for SARS
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
PPARA activates gene expression
Generic Transcription Pathway
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
Circadian Clock
Estrogen-dependent gene expression
Drugs
Flunisolide
Diflorasone
Alclometasone
Medrysone
Amcinonide
Fluorometholone
Megestrol acetate
Levonorgestrel
Beclomethasone dipropionate
Progesterone
Spironolactone
Betamethasone
Desoximetasone
Fluticasone propionate
Fluocinolone acetonide
Ulobetasol
Triamcinolone
Prednisone
Flumethasone
Fludrocortisone
Norethisterone
Hydrocortisone
Mometasone
Hydrocortamate
Mifepristone
Clocortolone
Flurandrenolide
Prednisolone
Loteprednol etabonate
Rimexolone
Methylprednisolone
Clobetasol propionate
Fluocinonide
Prednicarbate
Fluoxymesterone
Budesonide
Dexamethasone
Desonide
Cortisone acetate
Paramethasone
Drospirenone
Ciclesonide
Hexane-1,6-Diol
Aldosterone
ORG-34517
Difluprednate
Ulipristal
Fluticasone furoate
Tixocortol
Difluocortolone
Gestrinone
Deflazacort
Onapristone
Cortivazol
Clobetasone
Fluticasone
Mometasone furoate
Hydrocortisone aceponate
Hydrocortisone acetate
Hydrocortisone butyrate
Hydrocortisone cypionate
Hydrocortisone phosphate
Hydrocortisone probutate
Hydrocortisone valerate
Segesterone acetate
Prednisolone phosphate
Dexamethasone acetate
Betamethasone phosphate
Prednisolone acetate
Becocalcidiol
Diseases
46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency
GWAS
Atrial fibrillation (
30061737
29892015
)
Lymphocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Night sleep phenotypes (
27126917
)
PR interval (
32439900
)
Spatial processing (
31596458
)
Asthma (
31619474
)
Creatinine levels (
29403010
)
Estimated glomerular filtration rate (
30604766
)
Glomerular filtration rate (
29403010
)
Lung function (FVC) (
30061609
)
Refractive error (
32231278
)
Rheumatoid arthritis (
30423114
24390342
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Systemic lupus erythematosus (
24871463
)
Ulcerative colitis (
20228799
)
Interacting Genes
160 interacting genes:
ABCC1
ADA
AR
ARPC5
BAG1
C1orf94
CALM1
CALR
CEBPA
CEBPB
CENPB
CHD9
COPS6
CREB1
CREBBP
DAP3
DAPK1
DCAF6
DDX54
DNMT3L
DOCK3
DTD1
ECD
EFHC2
EGFR
EPB41L1
ETS1
ETS2
FAM161B
FKBP4
FTH1
FYN
GNB1
GNB2
GRIP1
H3C1
HDAC1
HDAC6
HMGB1
HMGB2
HMOX2
HNRNPA1
HNRNPU
HSP90AA1
HSP90AB1
HSPA1A
HSPD1
IDE
IFNGR2
JUN
KAT5
KDM5A
KPNA2
KRTCAP3
LCK
LPXN
LRIF1
MAFF
MAPK1
MAPK15
MAPK8
MDM2
MED1
MED14
MED25
MSX2
NCL
NCOA1
NCOA2
NCOA3
NCOA4
NCOA6
NCOR1
NCOR2
NEDD4L
NFKB1
NFKB2
NR0B1
NR0B2
NR1H3
NR2E3
NR2F2
NR2F6
NR3C2
NR4A1
NRIP1
NUP54
ONECUT1
OSGEP
PBX1
PELP1
PIAS2
PML
POLR1D
POU1F1
POU2F1
POU2F2
PPARGC1A
PRDX3
PRKACA
PRKDC
PRPF6
PSMC3IP
PTGES3
PTMS
RACK1
RAD54L2
RAD9A
RAF1
RAN
RARA
RBM14
RELA
RFPL2
RNF14
RXRB
SFN
SGTA
SHKBP1
SLC25A4
SMAD3
SMARCA2
SMARCA4
SMARCB1
SMARCC1
SMARCD1
SMARCE1
SPIN2A
SRA1
SRC
STAT3
STAT5A
STAT5B
STRN3
STUB1
SUMO1
SUMO4
SVIL
SYT1
TADA2A
TBP
TDG
TGFB1I1
TMF1
TNS4
TP53
TRIM24
TRIM28
TSG101
TXN
UBB
UBE2I
UBE2L3
WTIP
YWHAH
ZBTB16
ZBTB20
ZBTB3
ZBTB9
ZNF496
46 interacting genes:
AKAP9
AR
BRCA1
CASK
CTDP1
ESR1
ESR2
EZH2
GABPA
GATA1
GATA3
GATA4
GATA6
GJB5
HNF4A
KIF1A
MAPK3
MDM2
MED12
MED14
MED25
MED8
MED9
MYC
NCOA6
NR1H2
NR1I3
NR3C1
NR4A1
PIN1
PPARA
PPARG
PPARGC1A
RARA
RBM5
RORA
RPA2
RXRA
SREBF1
TET2
THRA
THRB
TP53
VDR
YWHAH
YWHAQ
Entrez ID
2908
5469
HPRD ID
00679
05055
Ensembl ID
ENSG00000113580
ENSG00000125686
Uniprot IDs
B7Z7I2
E5KQF5
E5KQF6
F1D8N4
P04150
Q15648
PDB IDs
1M2Z
1NHZ
1P93
3BQD
3CLD
3E7C
3H52
3K22
3K23
4CSJ
4HN5
4HN6
4LSJ
4MDD
4P6W
4P6X
4UDC
4UDD
5CBX
5CBY
5CBZ
5CC1
5E69
5E6A
5E6B
5E6C
5E6D
5EMC
5EMP
5EMQ
5G3J
5G5W
5NFP
5NFT
5UC3
5VA0
5VA7
6BQU
6CFN
6DXK
6EL6
6EL7
6EL9
1RJK
1RK3
1RKG
1RKH
2O4J
2O4R
2ZFX
3A2H
3AUN
3VJS
3VJT
3VRT
3VRU
3VRV
3VRW
3W0G
3W0H
3W0I
3W0J
3W5P
3W5Q
3W5R
3W5T
3WT5
3WT6
3WT7
3WTQ
4YNK
5AWJ
5AWK
5B41
5B5B
5GIC
5GID
5GIE
5XPM
5XPN
5XPO
5XPP
5XUQ
5XZF
5XZH
5ZWE
5ZWF
5ZWH
5ZWI
6D94
6JEZ
6K5O
6ONJ
Enriched GO Terms of Interacting Partners
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