MAD2L1BP and ANAPC4

Data Source:
BioGRID (pull down)

		MAD2L1BP	ANAPC4
Description		MAD2L1 binding protein	anaphase promoting complex subunit 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle Nuclear Membrane	Nucleus Nucleoplasm Anaphase-promoting Complex Cytosol Nuclear Periphery
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Protein Phosphatase Binding
	Biological Process	Regulation Of Exit From Mitosis Deactivation Of Mitotic Spindle Assembly Checkpoint	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition
Pathways			Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Adult body size ( 32376654) Body mass index ( 29273807) Body size at age 10 ( 32376654) General cognitive ability ( 29844566) Heel bone mineral density ( 30598549) Intelligence (MTAG) ( 29326435) Logical memory (immediate recall) in normal cognition ( 29274321) Multisite chronic pain ( 31194737) Weight ( 20966902)
Interacting Genes		21 interacting genes: ANAPC4 CDC20 CEP126 EEF1A1 FNDC8 HOMEZ IGSF21 INPP5K KAT5 KRT15 LRIF1 MAD2L1 MAD2L2 NMI PLK1 PTN SETDB1 TP53 TRIP13 ZBTB14 ZNF202	7 interacting genes: ANAPC11 CDC20 CDC27 MAD2L1 MAD2L1BP UBE2I UBE2S
Entrez ID		9587	29945
HPRD ID		10065	09505
Ensembl ID		ENSG00000124688	ENSG00000053900
Uniprot IDs		Q15013	B3KN47 Q9UJX5
PDB IDs		2QYF 6F0X	4UI9 5A31 5BPW 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5
Enriched GO Terms of Interacting Partners?
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