APOBEC3B and MSL2

Data Source:
BioGRID (enzymatic study)

		APOBEC3B	MSL2
Description		apolipoprotein B mRNA editing enzyme catalytic subunit 3B	MSL complex subunit 2
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GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm	Nucleoplasm MSL Complex
	Molecular Function	RNA Binding Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Deoxycytidine Deaminase Activity	Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cytidine Deamination Negative Regulation Of Transposition Cytidine To Uridine Editing Innate Immune Response Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Defense Response To Virus DNA Cytosine Deamination DNA Demethylation	Protein Ubiquitination Histone H4-K16 Acetylation
Pathways		mRNA Editing: C to U Conversion Formation of the Editosome	HATs acetylate histones
Drugs
Diseases
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Breast cancer ( 29059683) Response to methotrexate in juvenile idiopathic arthritis ( 24709693)	Alanine transaminase levels ( 29403010) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Blood urea nitrogen levels ( 31152163) C-reactive protein levels ( 30388399) Coronary artery disease ( 29212778 33020668) Estimated glomerular filtration rate ( 31152163) Fibrinogen ( 23969696) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 31217584) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lymphocyte percentage of white cells ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Schizophrenia ( 28991256 25056061 29483656) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		61 interacting genes: AGR2 BNIP2 MIR1-1 MIR1-2 MIR106A MIR10B MIR128-1 MIR128-2 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A2 MIR19A MIR19B1 MIR200A MIR200B MIR205 MIR20A MIR20B MIR21 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR9-1 MIR9-2 MIR9-3 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MSL2	13 interacting genes: APOBEC3B H2AC18 H2AC20 H2BC21 H3C14 H4C1 PAF1 TP53 TRIM8 UBE2D3 YWHAE YWHAG YWHAZ
Entrez ID		9582	55167
HPRD ID		06169	08550
Ensembl ID		ENSG00000179750	ENSG00000174579
Uniprot IDs		Q9UH17	Q9HCI7
PDB IDs		2NBQ 5CQD 5CQH 5CQI 5CQK 5SXG 5SXH 5TD5 5TKM 6NFK 6NFL 6NFM	4B7Y 4B86
Enriched GO Terms of Interacting Partners?
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