GABBR2 and TAMALIN

Data Source:
HPRD (two hybrid)

		GABBR2	TAMALIN
Description		gamma-aminobutyric acid type B receptor subunit 2	trafficking regulator and scaffold protein tamalin
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane G Protein-coupled Receptor Heterodimeric Complex Neuron Projection Postsynaptic Membrane GABA Receptor Complex	Plasma Membrane Postsynaptic Density Postsynaptic Membrane Perinuclear Region Of Cytoplasm Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled GABA Receptor Activity Protein Binding Protein Heterodimerization Activity	PDZ Domain Binding Identical Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Neuron-glial Cell Signaling	Signal Transduction Protein Localization Regulation Of Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane
Pathways		Activation of G protein gated Potassium channels G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) GABA B receptor activation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Baclofen gamma-Aminobutyric acid SGS-742 Arbaclofen Arbaclofen Placarbil
Diseases
GWAS		Gynecologic disease (multivariate analysis) ( 31488892) High chromosomal aberration frequency (chromatid type) ( 31586183) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Response to simvastatin treatment (PCSK9 protein level change) ( 25089948) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Schizophrenia ( 30285260) Systolic blood pressure change trajectories ( 27980656)
Interacting Genes		11 interacting genes: ATF4 ATF5 DRD2 GABBR1 GLP1R HTR1A KCTD12 KCTD16 NSF SH3GL3 TAMALIN	11 interacting genes: CYTH3 DLG4 DOCK1 FYN GABBR2 GRM1 GRM2 GRM3 GRM5 RPS6KA1 SRC
Entrez ID		9568	160622
HPRD ID		09552	17077
Ensembl ID		ENSG00000136928	ENSG00000161835
Uniprot IDs		H9NIL8 O75899	Q7Z6J2
PDB IDs		4F11 4F12 4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4 4PAS 6M8R 6OCP 6UO8 6UO9 6UOA 6VJM 6W2X 6WIV 7C7Q 7C7S	2PNT
Enriched GO Terms of Interacting Partners?
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